Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
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DOI: 10.1002/em.22444
Abstract: The organotypic human air‐liquid‐interface (ALI) airway tissue model has been used as an in vitro cell culture system for evaluating the toxicity of inhaled substances. ALI airway cultures are highly differentiated, which has made it… read more here.
Keywords: dna damage; airway cultures; toxicity; duplex sequencing ... See more keywords
Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated human airway cultures
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202101116
Abstract: There is an urgent need to develop novel therapeutic strategies to prevent viral transmission and COVID-19 disease—we show that topical application of camostat, a TMPRSS2 inhibitor, could be a simple, safe, and effective strategy for… read more here.
Keywords: airway cultures; cov infection; sars cov; human airway ... See more keywords