A GRIM fate for human neutrophils in airway disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5ce0418-162r
Abstract: Nowhere in biomedical research does a cell type seem as simultaneously vital and vexing as the neutrophil. Human immunity deteriorates rapidly in the absence of neutrophils whereas their dysfunctional abundance can cause misery and harm,… read more here.
Keywords: airway disease; sputum; drug; human neutrophils ... See more keywords
T Follicular Helper Cells in Asthma Through Murine Models of Allergic Airway Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_20
Abstract: The development of allergen-specific IgE is one of the hallmark symptoms of allergic diseases, including asthma. T follicular helper cells (TFH) are a subset of CD4+ T cells that play a critical role in T-dependent… read more here.
Keywords: allergic airway; airway disease; helper cells; follicular helper ... See more keywords
Epigenetics and the Environment in Airway Disease: Asthma and Allergic Rhinitis.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-3449-2_6
Abstract: Asthma and rhinitis are complex, heterogeneous diseases characterized by chronic inflammation of the upper and lower airways. While genome-wide association studies (GWAS) have identified a number of susceptible loci and candidate genes associated with the… read more here.
Keywords: allergic rhinitis; airway disease; rhinitis; epigenetic modifications ... See more keywords
Hydrogen water alleviates obliterative airway disease in mice
Sign Up to like & getrecommendations! Published in 2019 at "General Thoracic and Cardiovascular Surgery"
DOI: 10.1007/s11748-019-01195-3
Abstract: Objective Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia–reperfusion injury via anti-inflammatory and… read more here.
Keywords: hydrogen water; airway disease; obliterative airway; water ... See more keywords
MicroRNAs in Chronic Airway Diseases: Clinical Correlation and Translational Applications.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105045
Abstract: MicroRNAs (miRNAs) are short single-stranded RNAs that have pivotal roles in disease pathophysiology through transcriptional and translational modulation of important genes. It has been implicated in the development of many diseases, such as stroke, cardiovascular… read more here.
Keywords: airway disease; research; disease; airway diseases ... See more keywords
Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2016.11.017
Abstract: ABSTRACT Chlorine is a pulmonary toxicant to which humans can be exposed through accidents or intentional releases. Acute effects of chlorine inhalation in humans and animal models have been well characterized, but less is known… read more here.
Keywords: airway disease; small airway; chlorine; inhalation ... See more keywords
IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease.
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal immunology"
DOI: 10.1038/s41385-019-0232-7
Abstract: Airway hyperresponsiveness (AHR) often defines asthma. Murine allergic airway disease (AAD), like human eosinophilic asthma, is characterized by AHR, eosinophilia, goblet cell metaplasia (GCM), smooth muscle hypercontractility, and increased production of IL-4 and IL-13—cytokines that… read more here.
Keywords: airway disease; allergic airway; muscle; smooth muscle ... See more keywords
Microbiology of Cystic Fibrosis Airway Disease
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Respiratory and Critical Care Medicine"
DOI: 10.1055/s-0039-1698464
Abstract: Although survival of individuals with cystic fibrosis (CF) has been continuously improving for the past 40 years, respiratory failure secondary to recurrent pulmonary infections remains the leading cause of mortality in this patient population. Certain… read more here.
Keywords: airway disease; cystic fibrosis; fibrosis airway; microbiology ... See more keywords
Novel therapeutic approaches targeting endotypes of severe airway disease
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2021.1937132
Abstract: ABSTRACT Introduction: Severe asthma and chronic rhinosinusitis (CRS), with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP), are heterogeneous diseases characterized by different mechanistic pathways (endotypes) and variable clinical presentations (phenotypes). Areas covered: This review… read more here.
Keywords: severe airway; airway disease; therapeutic approaches; disease ... See more keywords
Airway disease in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2022.2043746
Abstract: ABSTRACT Introduction Hematologic malignancies are cancers of the blood, bone marrow and lymph nodes and represent a heterogenous group of diseases that affect people of all ages. Treatment generally involves chemotherapeutic or targeted agents that… read more here.
Keywords: bos bronchiectasis; hematologic malignancies; disease hematologic; treatment ... See more keywords
Using Pleth Variability as a Triage Tool for Children With Obstructive Airway Disease in a Pediatric Emergency Department
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Emergency Care"
DOI: 10.1097/pec.0000000000000887
Abstract: Objectives Patients with obstructive airway disease have varying degrees of pulsus paradoxus that correlate with illness severity. Pulsus paradoxus can be measured using plethysmography. We investigated whether plethysmograph (pleth) variability on admission to the pediatric… read more here.
Keywords: pediatric emergency; airway disease; pleth variability; obstructive airway ... See more keywords