High expression of sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0033-4
Abstract: Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We… read more here.
Keywords: allergic airway; airway epithelia; sonic hedgehog; expression ... See more keywords
Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia
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DOI: 10.1038/s41586-019-1018-5
Abstract: Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis1–3. Here we report that… read more here.
Keywords: cystic fibrosis; airway epithelia; fibrosis; ion channels ... See more keywords
WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia
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DOI: 10.1165/rcmb.2022-0172oc
Abstract: In cystic fibrosis (CF), reduced HCO3− secretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHASL) in CF may help identify novel targets… read more here.
Keywords: wnk inhibition; airway epithelia; surface liquid; host ... See more keywords
The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia.
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DOI: 10.1242/jcs.259512
Abstract: Mutations in SPAG1, a dynein axonemal assembly factor (DNAAF) that facilitates the assembly of dynein arms in the cytoplasm before their transport into the cilium, result in primary ciliary dyskinesia (PCD), a genetically heterogenous disorder… read more here.
Keywords: role spag1; spag1; dynein; airway epithelia ... See more keywords
Inter-individual Variation in Receptor Expression Influences MERS-CoV Infection and Immune Responses in Airway Epithelia
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DOI: 10.3389/fpubh.2021.756049
Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) causes respiratory infection in humans, with symptom severity that ranges from asymptomatic to severe pneumonia. Known risk factors for severe MERS include male sex, older age, and the presence… read more here.
Keywords: infection; mers cov; airway epithelia; receptor ... See more keywords