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Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0033-4
Abstract: Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We…
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Keywords:
allergic airway;
airway epithelia;
sonic hedgehog;
expression ... See more keywords
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Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1018-5
Abstract: Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO3− and Cl− secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis1–3. Here we report that…
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Keywords:
cystic fibrosis;
airway epithelia;
fibrosis;
ion channels ... See more keywords
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Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2022-0172oc
Abstract: In cystic fibrosis (CF), reduced HCO3− secretion acidifies the airway surface liquid (ASL), and the acidic pH disrupts host defenses. Thus, understanding the control of ASL pH (pHASL) in CF may help identify novel targets…
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Keywords:
wnk inhibition;
airway epithelia;
surface liquid;
host ... See more keywords
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Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259512
Abstract: Mutations in SPAG1, a dynein axonemal assembly factor (DNAAF) that facilitates the assembly of dynein arms in the cytoplasm before their transport into the cilium, result in primary ciliary dyskinesia (PCD), a genetically heterogenous disorder…
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Keywords:
role spag1;
spag1;
dynein;
airway epithelia ... See more keywords
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1
Published in 2022 at "Frontiers in Public Health"
DOI: 10.3389/fpubh.2021.756049
Abstract: Middle East respiratory syndrome coronavirus (MERS-CoV) causes respiratory infection in humans, with symptom severity that ranges from asymptomatic to severe pneumonia. Known risk factors for severe MERS include male sex, older age, and the presence…
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Keywords:
infection;
mers cov;
airway epithelia;
receptor ... See more keywords