The transient receptor potential vanilloid 1 (TRPV1) channel is a critical factor in allergen-induced innate immune responses in the airway epithelium
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.265
Abstract: The airway epithelium plays a critical role in innate responses to asthma-relevant protease allergens, such as house dust mite (HDM) or Alternaria alternata (ALT), by rapid secretion of IL-1 family alarmins, such as interleukin (IL)-1α… read more here.
Keywords: trpv1; secretion; activation; receptor ... See more keywords
Reconstituted basement membrane enables airway epithelium modeling and nanoparticle toxicity testing.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.02.018
Abstract: Basement membrane (BM) acts as a sheet-like extracellular matrix to support and promote the formation of epithelial and endothelial cell layers. The in-vitro reconstruction of the BM is however not easy due to its ultrathin… read more here.
Keywords: reconstituted basement; membrane; airway epithelium; toxicity ... See more keywords
Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2016.11.024
Abstract: Aims Azithromycin can benefit treating allergic airway inflammation and remodeling. In the present study, we hypothesized that azithromycin alleviated airway epithelium injury through inhibiting airway epithelium apoptosis via down regulation of caspase‐3 and Bax/Bcl2 ratio… read more here.
Keywords: bax; caspase; apoptosis; epithelium apoptosis ... See more keywords
Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54051-y
Abstract: Epidemiological studies have shown that female smokers are at higher risk of chronic obstructive pulmonary disease (COPD). Female patients have worse symptoms and health status and increased risk of exacerbations. We determined the differences in… read more here.
Keywords: response; response smoking; female smokers; human airway ... See more keywords
Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1301327
Abstract: ABSTRACT Enhanced macroautophagy/autophagy is recognized as a component of the pathogenesis of smoking-induced airway disease. Based on the knowledge that enhanced autophagy is linked to oxidative stress and the DNA damage response, both of which… read more here.
Keywords: autophagy human; smoking; small airway; smoking induced ... See more keywords
Differentially Expressed Genes Analysis in the Human Small Airway Epithelium of Healthy Smokers Shows Potential Risks of Disease Caused by Oxidative Stress and Inflammation and the Potentiality of Astaxanthin as an Anti-Inflammatory Agent
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Inflammation"
DOI: 10.1155/2023/4251299
Abstract: Cigarette smoke (CS) was known for its effect of increasing oxidative stress that could trigger tissue injury and endothelial dysfunction mediated by free radicals and reactive oxygen species (ROS). ROS itself is a key signaling… read more here.
Keywords: stress; inflammation; oxidative stress; expression ... See more keywords
Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202003-0541oc
Abstract: Rationale: Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease (COVID-19), a predominantly respiratory illness. The first step in SARS-CoV-2 infection is binding of the virus to ACE2 (angiotensin-converting enzyme 2)… read more here.
Keywords: expression; human airway; airway epithelium; sae ... See more keywords
Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma
Sign Up to like & getrecommendations! Published in 2022 at "ERJ Open Research"
DOI: 10.1183/23120541.00314-2022
Abstract: We congratulate Ravi et al. [1] for their recent paper in ERJ Open Research, “Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma”. We would like to discuss their study… read more here.
Keywords: viral infections; response respiratory; respiratory viral; airway epithelium ... See more keywords
Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059436
Abstract: ABSTRACT During airway branching morphogenesis, focal regions of FGF-10 expression in the pulmonary mesenchyme are thought to provide a local guidance cue, which promotes chemotactically the directional outgrowth of the airway epithelium. Here, however, we… read more here.
Keywords: morphogenesis; buckling morphogenesis; fgf promote; airway epithelium ... See more keywords
Current concepts on Pseudomonas aeruginosa interaction with human airway epithelium
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DOI: 10.1371/journal.ppat.1011221
Abstract: Pseudomonas aeruginosa is a major, but opportunistic, respiratory pathogen, which rarely infects healthy individuals, mainly due to the barrier effect of the human airway epithelium (HAE). This review explores the interaction of P. aeruginosa with… read more here.
Keywords: current concepts; pseudomonas aeruginosa; epithelium; airway epithelium ... See more keywords
Interleukin-13 Stimulation Reveals the Cellular and Functional Plasticity of the Airway Epithelium.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the American Thoracic Society"
DOI: 10.1513/annalsats.201711-868mg
Abstract: About 50% of patients with asthma exhibit chronic airway inflammation driven by the type 2 cytokines interleukin (IL)-4, IL-5, and IL-13. These patients with type 2-high asthma experience more allergic symptoms, greater airway hyperresponsiveness, and… read more here.
Keywords: mucin 5ac; stimulation; airway epithelial; mucus cells ... See more keywords