Rho‐kinase inhibitors protect against neonatal hyperoxia‐induced airway hyperreactivity in a rat pup model: Role of prostaglandin F2α
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.25848
Abstract: Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will attenuate airway hyperreactivity induced by… read more here.
Keywords: hyperoxia induced; rho kinase; induced airway; airway hyperreactivity ... See more keywords
Stiffening of the Extracellular Matrix is a Sufficient Condition for Airway Hyperreactivity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00554.2020
Abstract: The current therapeutic approach to asthma focuses exclusively on targeting inflammation and reducing airway smooth muscle force to prevent the recurrence of symptoms. However, even when inflammation is brought under control, airways in an asthmatic… read more here.
Keywords: matrix sufficient; stiffening extracellular; extracellular matrix; matrix ... See more keywords
Vagal C-fibers mediate HDM induced airway hyperreactivity via PAR1 receptors
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734190
Abstract: Airway hyperreactivity (AHR) is a hallmark of allergic asthma, and the major cause of exacerbations. Although acute bronchospasm can be mitigated by bronchodilators and corticosteroids, no therapeutics effectively target AHR. Recent studies have shown that… read more here.
Keywords: airway hyperreactivity; hdm; physiology; mice ... See more keywords
IL-5 Exposure in utero Increases Lung Nerve Density and Causes Airway Reactivity in Adult Offspring.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2019-0214oc
Abstract: Asthma is characterized by airway hyperreactivity and inflammation. In the lungs, parasympathetic and sensory nerves control airway tone and induce bronchoconstriction. Dysregulation of these nerves results in airway hyperreactivity. Humans with eosinophilic asthma have significantly… read more here.
Keywords: nerve; airway hyperreactivity; exposure; nerve density ... See more keywords
Maternal allergen exposure increases offspring sensory airway innervation and airway hyperreactivity in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa1380
Abstract: Background: Maternal asthma causes airway hyperreactivity in infants at birth and increases asthma risk in childhood. Humans with severe asthma have increased sensory nerve density in airways. Aim: We investigated whether maternal allergen exposure affects… read more here.
Keywords: exposure; innervation; exposed mothers; hdm ... See more keywords
Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.542818
Abstract: Asthma is a heterogeneous airway inflammatory disease characterized by increased airway hyperreactivity (AHR) to specific and unspecific stimuli. Group 2 innate lymphoid cells (ILC2)s are type-2 cytokine secreting cells capable of inducing eosinophilic lung inflammation… read more here.
Keywords: ilc2s; lfa icam; airway hyperreactivity; effector functions ... See more keywords
Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849155
Abstract: Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and pauci-granulocytic asthma have been best established. However, it is still puzzling what drives inflammation and airway hyperreactivity (AHR) in these patients and how… read more here.
Keywords: murine; asthma; model; neutrophilic asthma ... See more keywords