Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.138
Abstract: Airway hyperresponsiveness (AHR), airway remodeling and inflammation are the fundamental pathological alterations that occur in asthma. Transient receptor potential canonical 3 (TRPC3) has been implicated in diverse functions of airway smooth muscle cells (ASMCs) in… read more here.
Keywords: ova sensitized; sensitized mouse; airway hyperresponsiveness; inhibition trpc3 ... See more keywords
S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.033
Abstract: Airway hyperresponsiveness (AHR) is a major clinical problem in allergic asthma mainly caused by the hypercontractility of airway smooth muscles (ASM). S100A8 is an important member of the S100 calcium-binding protein family with a potential… read more here.
Keywords: asm contraction; airway hyperresponsiveness; contraction; s100a8 protein ... See more keywords
IL-4Rα expression by airway epithelium and smooth muscle accounts for nearly all airway hyperresponsiveness in murine allergic airway disease.
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal immunology"
DOI: 10.1038/s41385-019-0232-7
Abstract: Airway hyperresponsiveness (AHR) often defines asthma. Murine allergic airway disease (AAD), like human eosinophilic asthma, is characterized by AHR, eosinophilia, goblet cell metaplasia (GCM), smooth muscle hypercontractility, and increased production of IL-4 and IL-13—cytokines that… read more here.
Keywords: airway disease; allergic airway; muscle; smooth muscle ... See more keywords
Lactic Acid Bacteria and Natural Product Complex Ameliorates Ovalbumin-Induced Airway Hyperresponsiveness in Mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal food"
DOI: 10.1089/jmf.2020.4853
Abstract: The incidence of respiratory diseases, such as asthma, has substantially increased in recent times owing to environmental changes, such as air pollution. Induction of a chronic inflammatory response begins with production of biologically active mediators… read more here.
Keywords: hy2782 complex; acid bacteria; hy2782; airway hyperresponsiveness ... See more keywords
Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice
Sign Up to like & getrecommendations! Published in 2018 at "International Immunology"
DOI: 10.1093/intimm/dxy025
Abstract: Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse… read more here.
Keywords: house dust; mast cells; allergin; mice ... See more keywords
Impact of a Short-Term Water Abstinence on Airway Hyperresponsiveness in Elite Swimmers
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Journal of Sport Medicine"
DOI: 10.1097/jsm.0000000000000352
Abstract: Objective: To investigate the effect of a swimming break on airway hyperresponsiveness (AHR) and to evaluate perception of bronchoconstriction-related symptoms after methacholine challenge testing (MCT). Design: Observational, controlled study. Setting: University department. Participants: Overall, 25… read more here.
Keywords: term; water; water abstinence; control subjects ... See more keywords
Atrial septal defect in adults is associated with airway hyperresponsiveness
Sign Up to like & getrecommendations! Published in 2018 at "Congenital Heart Disease"
DOI: 10.1111/chd.12665
Abstract: OBJECTIVE The association between secundum atrial septal defects (ASD) and asthma-like dyspnea with consequent long-term pulmonary inhalant use, is poorly understood in adult ASD patients. Airway hyperresponsiveness is suggested to be the underlying mechanism of… read more here.
Keywords: atrial septal; adult asd; asd patients; airway hyperresponsiveness ... See more keywords
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aax3332
Abstract: Allergic inflammation and airway hyperresponsiveness in asthma are independently exacerbated by DGK activity. DGKζ activates airways Asthma is characterized by both T cell–mediated inflammation and airway smooth muscle cell hyperreactivity. In T cells, activation stimulates… read more here.
Keywords: dgk; inflammation; airway inflammation; inflammation airway ... See more keywords
Mechanism of Lower Airway Hyperresponsiveness Induced by Allergic Rhinitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/4351345
Abstract: Allergic rhinitis is a global illness that puzzles many researchers. Most patients with allergic rhinitis also have lower airway hyperresponsiveness, and an allergic rhinitis attack can increase lower airway hyperresponsiveness. However, the mechanism of the… read more here.
Keywords: airway hyperresponsiveness; rhinitis; lower airway; mechanism ... See more keywords
Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2765
Abstract: RATIONALE Indirect airway hyperresponsiveness (AHR) is a highly specific feature of asthma but the underlying mechanisms responsible for driving indirect AHR remain incompletely understood. OBJECTIVES Identify differences in gene expression in epithelial brushings obtained from… read more here.
Keywords: airway hyperresponsiveness; epithelial innate; distinct epithelial; asthma ... See more keywords
Airway Hyperresponsiveness Does Not Predict Morbidity in Children with Sickle Cell Anemia.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.201610-1970le
Abstract: Sickle cell anemia (SCA) is one of the most common inherited blood disorders in the world, characterized by chronic hemolytic anemia and recurrent vasoocclusive pain episodes. Pulmonary complications are a major cause of morbidity and… read more here.
Keywords: airway hyperresponsiveness; sickle cell; cell anemia; morbidity ... See more keywords