Iron Drives Eosinophil Differentiation in Allergic Airway Inflammation Through Mitochondrial Metabolic Adaptation
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202405085
Abstract: Eosinophils play a crucial role as effector cells in asthma pathogenesis, with their differentiation being tightly regulated by metabolic mechanisms. While the involvement of iron in various cellular processes is well known, its specific role… read more here.
Keywords: differentiation; iron; airway inflammation; eosinophil differentiation ... See more keywords
Tackling Allergic Airway Inflammation with Organic Sheet-Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202504197
Abstract: Allergic airway inflammatory disorders, such as allergic rhinitis (AR) and asthma, affect the health of more than one billion people worldwide, yet therapeutic outcomes remain unsatisfactory. 2D nanomaterials are extensively adopted in biomedical research, but… read more here.
Keywords: elimination epithelial; airway inflammation; inflammation; epithelial small ... See more keywords
The contribution of the WNT pathway to the therapeutic effects of montelukast in experimental murine airway inflammation induced by ovalbumin and lipopolysaccharide
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22178
Abstract: The wingless/integrase‐1 (WNT) pathway involved in the pathogenesis of inflammatory airway diseases has recently generated considerable research interest. Montelukast, a leukotriene receptor antagonist, provides therapeutic benefits in allergic asthma involving eosinophils. We aimed to investigate… read more here.
Keywords: induced ovalbumin; wnt pathway; airway inflammation; inflammation ... See more keywords
T cells and ILC2s are major effector cells in influenza‐induced exacerbation of allergic airway inflammation in mice
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201747421
Abstract: Influenza virus infection is an important cause of severe asthma exacerbations, but it remains unclear how a Th1‐mediated antiviral response triggers a prototypical Th2 disease. We investigated CD4+ T cells and group 2 innate lymphoid… read more here.
Keywords: cells ilc2s; induced exacerbation; airway inflammation; influenza induced ... See more keywords
Exopolysaccharide from Lacticaseibacillus rhamnosus induces IgA production in airways and alleviates allergic airway inflammation in mouse model.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250135
Abstract: The currently observed high prevalence of allergic diseases has been associated with changes in microbial exposure in industrialized countries. Defined bacterial components represent a new strategy for modulating the allergic immune response. We show that… read more here.
Keywords: airway inflammation; allergic airway; lacticaseibacillus rhamnosus; mouse model ... See more keywords
Activation of aryl hydrocarbon receptor by benzo[a]pyrene increases interleukin 33 expression and eosinophil infiltration in a mouse model of allergic airway inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4017
Abstract: We recently demonstrated that benzo[a]pyrene (BaP), the aryl hydrocarbon receptor (AhR) ligand, directly contributes to aggravation of cutaneous allergy in a mouse model of allergic dermatitis. The present study aimed to determine whether BaP‐induced AhR… read more here.
Keywords: airway inflammation; expression; activation; mouse model ... See more keywords
Fingolimod attenuates ovalbumin‐induced airway inflammation via inhibiting MAPK/ERK signaling in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23266
Abstract: The current study was designed to investigate the potential anti‐inflammatory and antioxidant effects of fingolimod against Ovalbumin (Ova)‐induced allergic airway inflammation compared to dexamethasone. Fingolimod was given (0.5 mg/kg/day, p.o.) for sensitized mice 1 h before Ova… read more here.
Keywords: inflammation; ova induced; fingolimod; airway inflammation ... See more keywords
Eupatorin Mitigates Airway Inflammation in Ovalbumin‐Induced Allergic Asthma in Mice by Regulating Th2 Cytokines and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70219
Abstract: Asthma is a prevalent airway inflammatory condition caused by exposure to various allergens. It is defined by the presence of airway inflammation, airway hyperresponsiveness, and excessive production of mucus. This work was undertaken to study… read more here.
Keywords: mice; asthma mice; airway inflammation; raw 264 ... See more keywords
Assessment of airway inflammation and remodeling in children with severe asthma: The next challenge
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24051
Abstract: Severe Asthma (SA) in children is relatively rare, affecting 2-5% of the asthmatic pediatric population. However, its burden is disproportionally high, as children with SA experience frequent asthma attacks, have a reduced quality of life,… read more here.
Keywords: inflammation remodeling; inflammation; airway inflammation; bronchial mucosa ... See more keywords
Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7051
Abstract: Abscisic acid (ABA), a well‐known natural phytohormone reportedly exerts anti‐inflammatory and anti‐oxidative properties in diabetes and colitis. However, the efficacy of ABA against allergic airway inflammation and the underlying mechanism remain unknown. Herein, an OVA‐induced… read more here.
Keywords: allergic airway; inflammation; airway inflammation; nlrp3 inflammasome ... See more keywords
Acute iron oxide nanoparticles exposure induced murine eosinophilic airway inflammation via TLR2 and TLR4 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23455
Abstract: Iron oxide nanoparticles (Fe2O3 NPs) is the main component of air pollution particles in urban rail transit environment. People are more exposed to Fe2O3 NPs, however, the studies on relationship between Fe2O3 NPs and respiratory… read more here.
Keywords: fe2o3 nps; airway inflammation; tlr2 tlr4;