Elevated MUC1 and MUC5AC mucin protein levels in airway mucus of critical ill COVID‐19 Patients
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26406
Abstract: Abstract Coronavirus disease 2019 (COVID‐19) patients exhibit a spectrum of respiratory symptoms like cough and dyspnea1‐3. Airway mucus is an adhesive viscoelastic gel composed mostly of high‐molecular weight mucous glycoproteins and water, which is important… read more here.
Keywords: covid patients; elevated muc1; mucin; muc1 muc5ac ... See more keywords
Enhancing nanoparticle penetration through airway mucus to improve drug delivery efficacy in the lung
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2021.1854222
Abstract: ABSTRACT Introduction: Airway mucus gel layer serves as a key delivery barrier that limits the performance of inhaled drug delivery nanoparticles. Conventional nanoparticles are readily trapped by the airway mucus and rapidly cleared from the… read more here.
Keywords: drug delivery; delivery; penetration airway; airway mucus ... See more keywords
Effects of Mucin and DNA Concentrations in Airway Mucus on Pseudomonas aeruginosa Biofilm Recalcitrance
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00291-22
Abstract: Pathological mucus in cystic fibrosis (CF) is highly concentrated and insufficiently cleared from the airway, causing chronic inflammation and infection. Pseudomonas aeruginosa establishes chronic infection in the form of biofilms within mucus, and this study… read more here.
Keywords: pseudomonas aeruginosa; concentrated mucus; infection; concentration ... See more keywords
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202002-0369oc
Abstract: RATIONALE Animal models have been highly informative for understanding characteristics, onset, and progression of cystic fibrosis (CF) lung disease. In particular, the CFTR-/- rat has revealed insights into the airway mucus defect characteristic of CF,… read more here.
Keywords: airway mucus; rat; g551d; ivacaftor reverses ... See more keywords
The Mucin Gene MUC5B Is Required for Normal Lung Function
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202201-0064ed
Abstract: Airways have a mucus lining that protects the lungs from the deleterious effects of exposure to inhaled particles, pathogens, and gases. Airway mucus is a gel in which the polymer network consists of heavily glycosylated… read more here.
Keywords: mucus gel; lung; pathology; airway mucus ... See more keywords