Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00114
Abstract: To deal with the broad spectrum of coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), that threaten human health, it is essential to not only drugs develop that target viral proteins but also consider… read more here.
Keywords: airway organoids; infection; coronavirus; related compounds ... See more keywords
Airway organoids as models of human disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13075
Abstract: Studies developing and applying organoid technology have greatly increased in volume and visibility over the past decade. Organoids are three‐dimensional structures that are established from pluripotent stem cells (PSCs) or adult tissue stem cells (ASCs).… read more here.
Keywords: organoids models; physiology; models human; human disease ... See more keywords
Evaluating Bacterial Pathogenesis Using a Model of Human Airway Organoids Infected with Pseudomonas aeruginosa Biofilms
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02408-22
Abstract: Human airway organoids (HAOs) are an organotypic model of human airway mucociliary epithelium. The HAOs can closely resemble their origin organ in terms of epithelium architecture and physiological function. ABSTRACT Pseudomonas aeruginosa is one of… read more here.
Keywords: airway organoids; haos; model; model human ... See more keywords
Modelling of primary ciliary dyskinesia using patient-derived airway organoids.
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202052058
Abstract: Patient-derived human organoids can be used to model a variety of diseases. Recently, we described conditions for long-term expansion of human airway organoids (AOs) directly from healthy individuals and patients. Here, we first optimize differentiation… read more here.
Keywords: primary ciliary; modelling primary; ciliary dyskinesia; airway organoids ... See more keywords
Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202101320
Abstract: This work describes an optimized assay to determine CFTR drug responses in people with cystic fibrosis, using nasal-airway organoids that are generated from 2D differentiated epithelial monolayers. Cystic fibrosis is caused by genetic defects that… read more here.
Keywords: measuring cystic; drug responses; airway organoids; fibrosis ... See more keywords
Human airway organoids as 3D in vitro models for a toxicity assessment of emerging inhaled pollutants: Tire wear particles
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1105710
Abstract: Three-dimensional (3D) structured organoids have become increasingly promising and effective in vitro models, and there is an urgent need for reliable models to assess health effects of inhaled pollutants on the human airway. In our… read more here.
Keywords: airway organoids; tire wear; emerging inhaled; human airway ... See more keywords
Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15051166
Abstract: The respiratory epithelium, particularly the airway epithelium, is the primary infection site for respiratory pathogens. The apical surface of epithelial cells is constantly exposed to external stimuli including invading pathogens. Efforts have been made to… read more here.
Keywords: apical airway; airway organoids; infection; airway ... See more keywords