A theoretical model of inflammation- and mechanotransduction-driven asthmatic airway remodelling
Sign Up to like & getrecommendations! Published in 2018 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-018-1037-4
Abstract: Inflammation, airway hyper-responsiveness and airway remodelling are well-established hallmarks of asthma, but their inter-relationships remain elusive. In order to obtain a better understanding of their inter-dependence, we develop a mechanochemical morphoelastic model of the airway… read more here.
Keywords: airway remodelling; inflammation; inflammation mechanotransduction; theoretical model ... See more keywords
Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2016.12.003
Abstract: BACKGROUND AND AIMS In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling,… read more here.
Keywords: airway remodelling; ursodeoxycholic acid; apoptosis; effects ursodeoxycholic ... See more keywords
DEK‐targeting aptamer DTA‐64 attenuates bronchial EMT‐mediated airway remodelling by suppressing TGF‐β1/Smad, MAPK and PI3K signalling pathway in asthma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15942
Abstract: This study is to investigate the inhibitory effects and mechanisms of DEK‐targeting aptamer (DTA‐64) on epithelial mesenchymaltransition (EMT)‐mediated airway remodelling in mice and human bronchial epithelial cell line BEAS‐2B. In the ovalbumin (OVA)‐induced asthmatic mice,… read more here.
Keywords: dta; pi3k; emt; airway remodelling ... See more keywords
Anti-fibrotic effect of ciglitazone in HRV-induced airway remodelling cell model.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17790
Abstract: Fibrosis is an important phenomenon as it can occur early in the pathogenesis of asthma; it may be associated with disease severity and resistance to therapy. There is a strong evidence that infection caused by… read more here.
Keywords: ppar agonist; hrv; expression; airway remodelling ... See more keywords
ZEB1 recruits BRG1 to regulate airway remodelling epithelial‐to‐mesenchymal transition in asthma
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Physiology"
DOI: 10.1113/ep090212
Abstract: What is the central question of this study? The aim was to investigate the function of brahma‐related gene‐1 (BRG1) in airway remodelling epithelial‐to‐mesenchymal transition (EMT) of asthma and identify the transcription factor of BRG1 that… read more here.
Keywords: remodelling epithelial; mesenchymal transition; asthma; airway remodelling ... See more keywords
CT airway remodelling and chronic cough
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Open Respiratory Research"
DOI: 10.1136/bmjresp-2022-001462
Abstract: Rationale Structural airway changes related to chronic cough (CC) are described in the literature, but so far reported data are rare and non-conclusive. Furthermore, they derive mainly from cohorts with small sample sizes. Advanced CT… read more here.
Keywords: decline; remodelling chronic; chronic cough; cough ... See more keywords
S37 A novel computational image analysis method gives comprehensive insight into airway remodelling and resolution in the ovalbumin model of asthma
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thorax-2018-212555.43
Abstract: Background The pathophysiological changes occurring during the onset and progression of airway remodelling in asthma are intensively researched. However, protocols examine only a small fraction of airways and resolution of remodelling is barely examined. A… read more here.
Keywords: collagen; resolution; airway remodelling; airways respectively ... See more keywords
Does Inhalation of Virgin Coconut Oil Accelerate Reversal of Airway Remodelling in an Allergic Model of Asthma?
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Inflammation"
DOI: 10.1155/2017/8741851
Abstract: Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and… read more here.
Keywords: airway remodelling; coconut oil; inhalation; virgin coconut ... See more keywords
“Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts.” Qingzhu Sun, Lei Fang, Michael Roth, et al. Eur Respir J 2019; 54: 1900300.
Sign Up to like & getrecommendations! Published in 2021 at "European Respiratory Journal"
DOI: 10.1183/13993003.50300-2019
Abstract: Figure 8 from the above mentioned article was originally published in an incorrect form. The first three immunofluorescence image panels in figure 8b were inadvertently duplicated from figure 7b. The corrected figure 8 with the… read more here.
Keywords: remodelling blocking; airway remodelling; blocking epithelium; thermoplasty decreases ... See more keywords
Epidermal growth factor receptor in airway remodelling during allergic airway disease – divergent roles during early life and adulthood?
Sign Up to like & getrecommendations! Published in 2021 at "ERJ Open Research"
DOI: 10.1183/23120541.lsc-2021.19
Abstract: Lung function deficits established in asthmatic children persist into adulthood, but the mechanisms are not well understood. Airway remodelling is a key pathological feature of paediatric and adult asthma and may contribute to loss of… read more here.
Keywords: lung; early life; adult; airway remodelling ... See more keywords
Neurokinin 1 receptor promotes rat airway smooth muscle cell migration in asthmatic airway remodelling by enhancing tubulin expression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.07.114
Abstract: Background Airway remodelling is a major contributor to hyper-responsiveness leading to chronic asthma; however, the underlying mechanisms remain unclear. This study aimed to investigate the effects of a neurokinin 1 receptor (NK1R) antagonist (WIN62577) on… read more here.
Keywords: airway remodelling; neurokinin receptor; group; migration ... See more keywords