TRPC3 overexpression and intervention in airway smooth muscle of ovalbumin‐induced hyperresponsiveness and remodeling
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10970
Abstract: Transient receptor potential canonical channel 3 (TRPC3) proteins function as non‐voltage‐gated Ca2+‐permeable channels and play divergent roles in many processes of pathophysiology. The purpose of this study was to determine the relationship between TRPC3 expression… read more here.
Keywords: trpc3; hyperresponsiveness remodeling; smooth muscle; mice ... See more keywords
Calcium sensing receptor in developing human airway smooth muscle
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28115
Abstract: Airway smooth muscle (ASM) regulation of airway structure and contractility is critical in fetal/neonatal physiology in health and disease. Fetal lungs experience higher Ca2+ environment that may impact extracellular Ca2+ ([Ca2+]o) sensing receptor (CaSR). Well‐known… read more here.
Keywords: physiology; casr; smooth muscle; ca2 ... See more keywords
p116Rip promotes myosin phosphatase activity in airway smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28949
Abstract: Myosin phosphatase‐Rho interacting protein (p116Rip) was originally found as a RhoA‐binding protein. Subsequent studies by us and others revealed that p116Rip facilitates myosin light chain phosphatase (MLCP) activity through direct and indirect manners. However, it… read more here.
Keywords: phosphatase; myosin phosphatase; smooth muscle; p116rip ... See more keywords
Glial-derived neurotrophic factor in human airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30489
Abstract: Airway smooth muscle (ASM) cells modulate the local airway milieu via production of inflammatory mediators and growth factors including classical neurotrophins, such as brain-derived neurotrophic factor (BDNF). The glial cell-derived neurotrophic factor (GDNF) family of… read more here.
Keywords: derived neurotrophic; asm; smooth muscle; neurotrophic factor ... See more keywords
Neurotrophin Regulation and Signaling in Airway Smooth Muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-68748-9_7
Abstract: Structural and functional aspects of bronchial airways are key throughout life and play critical roles in diseases such as asthma. Asthma involves functional changes such as airway irritability and hyperreactivity, as well as structural changes… read more here.
Keywords: regulation signaling; neurotrophin regulation; smooth muscle; signaling airway ... See more keywords
Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108897
Abstract: Diseases such as asthma are exacerbated by inflammation, cigarette smoke and even nicotine delivery devices such as e-cigarettes. However, there is currently little information on how nicotine affects airways, particularly in humans, and changes in… read more here.
Keywords: nicotinic acetylcholine; 7nachr human; smooth muscle; acetylcholine receptor ... See more keywords
S100A8 protein attenuates airway hyperresponsiveness by suppressing the contraction of airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.033
Abstract: Airway hyperresponsiveness (AHR) is a major clinical problem in allergic asthma mainly caused by the hypercontractility of airway smooth muscles (ASM). S100A8 is an important member of the S100 calcium-binding protein family with a potential… read more here.
Keywords: asm contraction; airway hyperresponsiveness; contraction; s100a8 protein ... See more keywords
Polarization Sensitive Optical Coherence Tomography for Bronchoscopic Airway Smooth Muscle Detection in Bronchial Thermoplasty-Treated Patients With Asthma
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.03.042
Abstract: Asthma is a chronic inflammatory disease characterized by airway remodeling (AR), including thickening of airway smooth muscle (ASM) as a key element of this alteration. Patients with severe asthma may benefit from bronchial thermoplasty (BT),… read more here.
Keywords: coherence tomography; optical coherence; smooth muscle; airway smooth ... See more keywords
SOX18 enhances the proliferation and migration of airway smooth muscle cells induced by tumor necrosis factor-α via the regulation of Notch1 signaling.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107746
Abstract: Childhood asthma is a frequent chronic disease of pediatric populations. The excessive proliferation and migration of airway smooth muscle cells contribute to airway remodeling during asthma pathogenesis. Sex-determining region on the Y chromosome-related high mobility… read more here.
Keywords: proliferation migration; sox18; muscle cells; smooth muscle ... See more keywords
Protocatechuic acid inhibits TGF-β1-induced proliferation and migration of human airway smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.10.011
Abstract: Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is a major metabolite of anthocyanins and was reported to possess anti-allergic response. However, the effects of PCA on airway smooth muscle cells (ASMCs) proliferation and migration remain unclear.… read more here.
Keywords: proliferation migration; protocatechuic acid; proliferation; migration ... See more keywords
Mechanopharmacology of Rho-kinase antagonism in airway smooth muscle and potential new therapy for asthma.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104995
Abstract: The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening… read more here.
Keywords: mechanopharmacology; muscle; smooth muscle; rho kinase ... See more keywords