Aerosolizing Lipid Dispersions Enables Antibiotic Transport Across Mimics of the Lung Airway Surface Even in the Presence of Pre-existing Lipid Monolayers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2017.1412
Abstract: BACKGROUND Secondary lung infections are the primary cause of morbidity associated with cystic fibrosis lung disease. Aerosolized antibiotic inhalation is potentially advantageous but has limited effectiveness due to altered airway aerodynamics and deposition patterns that… read more here.
Keywords: dppc; presence; surface; surface tension ... See more keywords
Culture with apically applied healthy or disease sputum alters the airway surface liquid proteome and ion transport across human bronchial epithelial cells
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Physiology - Cell Physiology"
DOI: 10.1152/ajpcell.00234.2021
Abstract: Airway secretions contain many signaling molecules and peptides/proteins that are not found in airway surface liquid (ASL) generated by normal human bronchial epithelial cells (NHBEs) in vitro. These play a key role in innate defense… read more here.
Keywords: surface liquid; culture; apically applied; airway surface ... See more keywords
Airway surface hyperviscosity and defective mucociliary transport by IL-17/TNF-α are corrected by β-adrenergic stimulus
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.164944
Abstract: The fluid covering the surface of airway epithelia represents a first barrier against pathogens. The chemical and physical properties of the airway surface fluid are controlled by the activity of ion channels and transporters. In… read more here.
Keywords: surface hyperviscosity; tnf; transport; hyperviscosity defective ... See more keywords
Naringenin Regulates Lipopolysaccharide-Induced Abnormal Airway Surface Liquid Secretion
Sign Up to like & getrecommendations! Published in 2021 at "Natural Product Communications"
DOI: 10.1177/1934578x211040356
Abstract: Airway surface liquid (ASL) is one of the key factors affecting the respiratory system's physiological function. Abnormal ASL secretion can increase the incidence of various respiratory diseases. Lipopolysaccharide (LPS) stimulation can damage the airway epithelial… read more here.
Keywords: airway surface; asl secretion; secretion; induced abnormal ... See more keywords
Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques
Sign Up to like & getrecommendations! Published in 2019 at "Respiratory Research"
DOI: 10.1186/s12931-019-1229-1
Abstract: By airway surface liquid, we mean a thin fluid continuum consisting of the airway lining layer and the alveolar lining layer, which not only serves as a protective barrier against foreign particles but also contributes… read more here.
Keywords: surface liquid; rheology; surface tension; airway surface ... See more keywords
Nominal carbonic anhydrase activity minimizes airway‐surface liquid pH changes during breathing
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13569
Abstract: The airway‐surface liquid pH (pHASL) is slightly acidic relative to the plasma and becomes more acidic in airway diseases, leading to impaired host defense. CO2 in the large airways decreases during inspiration (0.04% CO2) and… read more here.
Keywords: carbonic anhydrase; phasl; airway surface; anhydrase activity ... See more keywords
Allicin Facilitates Airway Surface Liquid Hydration by Activation of CFTR
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.890284
Abstract: Airway epithelium plays critical roles in regulating airway surface liquid (ASL), the alteration of which causes mucus stasis symptoms. Allicin is a compound released from garlic and harbors the capacity of lung-protection. However, the potential… read more here.
Keywords: activation cftr; cftr; airway epithelium; surface liquid ... See more keywords