Glucose increases the length and spacing of the lattice structure of the axon initial segment
Sign Up to like & getrecommendations! Published in 2022 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24122
Abstract: The axon initial segment (AIS) plays an important role in maintaining neuronal polarity and initiating action potentials (APs). The AIS adapts to its environment by changing its length and distance from the cell body, resulting… read more here.
Keywords: structure; microscopy; lattice structure; ais plasticity ... See more keywords
Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2513363122
Abstract: The developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initiates action potential. Studies have demonstrated that the… read more here.
Keywords: mice; plasticity; excitability; ankyrin ... See more keywords
Actin polymerization and longitudinal actin fibers in axon initial segment plasticity
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1376997
Abstract: The location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS… read more here.
Keywords: longitudinal actin; actin fibers; plasticity; actin polymerization ... See more keywords