A new abietane diterpenoid from Ajuga ovalifolia var. calantha induces human lung epithelial A549 cell apoptosis by inhibiting SHP2.
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DOI: 10.1016/j.fitote.2020.104484
Abstract: The Src-homology 2 domain-containing phosphatase 2 (SHP2), encoded by PTPN11, has been reported oncogenic tyrosine phosphatase associated with various tumors and played critical roles in many cell signaling events. Targeting SHP2 by small molecules may… read more here.
Keywords: shp2; ajuga ovalifolia; abietane diterpenoid; var calantha ... See more keywords
Ajudecumin A from Ajuga ovalifolia var. calantha exhibits anti-inflammatory activity in lipopolysaccharide-activated RAW264.7 murine macrophages and animal models of acute inflammation
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DOI: 10.1080/13880209.2018.1543331
Abstract: Abstract Context: Ajuga ovalifolia Bur. et Franch. var. calantha (Diels) C. Y. Wu et C. Chen (Labiatae), a traditional Chinese medicine, has been used to treat several inflammatory diseases. Objective: To assess the anti-inflammatory activity… read more here.
Keywords: anti inflammatory; ajuga ovalifolia; ajudecumin; inflammatory activity ... See more keywords
A new abietane diterpenoid glycoside from ajuga ovalifolia var. calantha
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DOI: 10.1080/14786419.2018.1500574
Abstract: Abstract A new abietane diterpenoid glycoside, ajugaside B (1), along with three known compounds (2–4), were isolated from the whole plants of Ajuga ovalifolia var. calantha. The structure of the new compound (1) was elucidated… read more here.
Keywords: ajuga ovalifolia; abietane diterpenoid; var calantha; diterpenoid glycoside ... See more keywords