Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
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DOI: 10.1038/s41589-020-0544-7
Abstract: Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane.… read more here.
Keywords: akba; insights lipoxygenase; inhibition; structural mechanistic ... See more keywords
Nrf2/HO-1 Signaling Stimulation through Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) Provides Neuroprotection in Ethidium Bromide-Induced Experimental Model of Multiple Sclerosis
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DOI: 10.3390/genes13081324
Abstract: Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by neuroinflammation, demyelination, and axonal degeneration in the central nervous system (CNS). This is frequently linked to motor abnormalities and cognitive impairments. The pathophysiological hallmarks… read more here.
Keywords: acetyl keto; sclerosis; akba; brain ... See more keywords
The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
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DOI: 10.3390/nu15071660
Abstract: This study examined the protective effect of 11-keto-β-boswellic acid (AKBA) against streptozotocin (STZ)-induced diabetic cardiomyopathy (DC) in rats and examined the possible mechanisms of action. Male rats were divided into 5 groups (n = 8/each):… read more here.
Keywords: keto boswellic; akba; effect keto; protective effect ... See more keywords