AKG induces cell apoptosis by inducing reactive oxygen species‐mediated endoplasmic reticulum stress and by suppressing PI3K/AKT/mTOR‐mediated autophagy in renal cell carcinoma
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DOI: 10.1002/tox.23658
Abstract: Background: Alpha‐ketoglutarate (AKG) or 2‐oxoglutarate is a key substance in the tricarboxylic acid cycle (TCA) and has been known to play an important role in cancerogenesis and tumor progression. Renal cell carcinoma (RCC) is the… read more here.
Keywords: cell carcinoma; akg induces; renal cell; akg ... See more keywords