Comparison of the Effects of Insulin and SGLT2 Inhibitor on the Renal Renin-Angiotensin System in Type 1 Diabetes Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2020.108107
Abstract: AIMS SGLT2 inhibitors have been proposed as an adjunct to insulin therapy for glycemic control in type 1 diabetes (T1D) patients. However, concern has been raised due to an increase in renin-angiotensin-system (RAS) activity reported… read more here.
Keywords: insulin; sglt2 inhibitor; akita mice; mice ... See more keywords
Enhanced Intrarenal pro-renin and salt sensitive hypertension in a mouse model of Type-1 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5735218
Abstract: Hypertension affects up to 50% of patients with type 1 diabetes. Despite aggressive anti-hypertensive therapy, at least 30% of diabetic patients develop chronic kidney disease. Renin is the rate-limiting enzyme in the activation of the… read more here.
Keywords: hypertension; physiology; renin; akita mice ... See more keywords
Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing
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DOI: 10.1371/journal.pone.0182828
Abstract: Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. Insulin2 mutant (Ins2+/-) Akita is a mouse model of T1DM, which manifests cardiac dysfunction.… read more here.
Keywords: heart; akita mice; diabetic akita; cardiac transcriptome ... See more keywords
Targeted disruption of glycogen synthase kinase-3β in cardiomyocytes attenuates cardiac parasympathetic dysfunction in type 1 diabetic Akita mice
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DOI: 10.1371/journal.pone.0215213
Abstract: Type 1 diabetic Akita mice develop severe cardiac parasympathetic dysfunction that we have previously demonstrated is due at least in part to an abnormality in the response of the end organ to parasympathetic stimulation. Specifically,… read more here.
Keywords: parasympathetic dysfunction; akita mice; gsk3; type ... See more keywords
A Low-Carbohydrate Diet Improves Glucose Metabolism in Lean Insulinopenic Akita Mice Along With Sodium-Glucose Cotransporter 2 Inhibitor
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DOI: 10.3389/fendo.2020.601594
Abstract: Objective A low-carbohydrate diet (LC) can be beneficial to obese subjects with type2 diabetes mellitus (T2DM). Sodium-glucose cotransporter 2 inhibitor (SGLT2i) presents prompt glucose-lowering effects in subjects with T2DM. We investigated how LC and SGLT2i… read more here.
Keywords: akita mice; carbohydrate diet; mice; low carbohydrate ... See more keywords
Type 1 Diabetes Induces Hearing Loss: Functional and Histological Findings in An Akita Mouse Model
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DOI: 10.3390/biomedicines8090343
Abstract: The relationship between type 1 diabetes and hearing loss is not well known, although based on many pathological studies, type 2 diabetes induced hearing loss is associated with microcirculation problems in the inner ear. The… read more here.
Keywords: hearing loss; type diabetes; akita mice; diabetes induces ... See more keywords