Loss of AKR1C1 is a good prognostic factor in advanced NPC cases and increases chemosensitivity to cisplatin in NPC cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15291
Abstract: Cisplatin resistance is one of the main obstacles in the treatment of advanced nasopharyngeal carcinoma (NPC). AKR1C1 is a member of the Aldo‐keto reductase superfamily (AKRs), which converts aldehydes and ketones to their corresponding alcohols… read more here.
Keywords: good prognostic; prognostic factor; cisplatin; npc cells ... See more keywords
Liquiritin, as a Natural Inhibitor of AKR1C1, Could Interfere With the Progesterone Metabolism
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DOI: 10.3389/fphys.2019.00833
Abstract: Low progesterone level is always linked with pre-term birth. Therefore, maintaining of progesterone level is vital during pregnancy. Aldo-keto reductase family one member C1 (AKR1C1) catalyzes the reduction of progesterone to its inactive form of… read more here.
Keywords: inhibitor akr1c1; akr1c1; progesterone metabolism; progesterone ... See more keywords
The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer
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DOI: 10.7150/thno.39151
Abstract: Aldo-keto reductase family 1 member C1 (AKR1C1) promotes malignancy of Non-Small Cell Lung Cancer (NSCLC) by activating Signal Transducer and Activator of Transcription 3 (STAT3) pathway. However, how the pro-metastatic functions of AKR1C1 are switched… read more here.
Keywords: acetylation; lung cancer; cell lung; akr1c1 ... See more keywords