MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12102
Abstract: Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors.… read more here.
Keywords: erk; mek inhibitors; akt activation; activation ... See more keywords
BCA3 contributes to the malignant progression of hepatocellular carcinoma through AKT activation and NF‐&kgr;B translocation
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.11.011
Abstract: Abstract Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide with elusive molecular mechanisms. The aim of this study is to investigate the clinical significance and biological roles of breast cancer‐associated protein 3… read more here.
Keywords: akt activation; translocation; bca3; hcc ... See more keywords
AKT activation is a feature of CALR mutant myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0224-8
Abstract: Among the driver mutations in the MPNs, the mechanism by which CALR mutations activate JAK/STAT signaling is unique in that the novel C-terminus of CALR mutant proteins binds directly to MPL leading to constitutive activation… read more here.
Keywords: calr; akt activation; calr mutant;
TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17802-4
Abstract: Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, a Ca2+ channel-like protein, is highly up-regulated in several cancer types. Here, we show that TMBIM6 is closely associated with survival in patients with… read more here.
Keywords: tmbim6; akt activation; cancer; progression ... See more keywords
Myo-Inositol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy by Inhibiting PI3K/AKT Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal food"
DOI: 10.1089/jmf.2022.k.0152
Abstract: Emerging evidence suggests that myo-inositol (MI) has a critical role in reducing renal inflammatory processes and improving podocyte function and preventing diabetes-related renal damage. We aimed to explore the function and underlying workings of MI… read more here.
Keywords: pi3k akt; myo inositol; interstitial fibrosis; renal interstitial ... See more keywords
Vaspin promotes chondrogenic differentiation of BMSCs via Akt activation in osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-022-05295-9
Abstract: Background The aim of this study was to investigate the role of Vaspin on the chondrogenic differentiation of bone mesenchymal stem cells (BMSCs), and its effect on chondrocyte survival and ECM secretion. We also assessed… read more here.
Keywords: differentiation; chondrogenic differentiation; vaspin; akt activation ... See more keywords
Sera from women with different metabolic and menopause states differentially regulate cell viability and Akt activation in a breast cancer in-vitro model
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266073
Abstract: Obesity is associated with an increased incidence and aggressiveness of breast cancer and is estimated to increment the development of this tumor by 50 to 86%. These associations are driven, in part, by changes in… read more here.
Keywords: activation; sera; breast cancer; akt activation ... See more keywords
CDKL3 promotes osteosarcoma progression by activating Akt/PKB
Sign Up to like & getrecommendations! Published in 2020 at "Life Science Alliance"
DOI: 10.26508/lsa.202000648
Abstract: This study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS. Osteosarcoma (OS) is a primary malignant bone neoplasm with high… read more here.
Keywords: akt activation; akt pkb; progression; cdkl3 ... See more keywords
Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00070
Abstract: The serine/threonine kinase Akt is a master regulator of many diverse cellular functions, including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine kinases are critical regulators of Akt, as a result of activation of phosphatidylinositol-3-kinase… read more here.
Keywords: kinase; akt activation; receptor tyrosine; activation ... See more keywords
Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20112731
Abstract: Esculetin, a bioactive 6,7-dihydroxy derivative of coumarin, possesses pharmacological activities against obesity, diabetes, renal failure, and cardiovascular disorders (CVDs). Platelet activation plays a major role in CVDs. Thus, disrupting platelet activation represents an attractive therapeutic… read more here.
Keywords: human platelets; plc pkc; akt activation; platelet activation ... See more keywords
Oxyresveratrol Inhibits TNF-α-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14010063
Abstract: Psoriasis is a complex inflammatory disease characterized by hyperproliferative keratinocyte caused by active PI3K/AKT signaling. TNF-α concentrated in the psoriatic lesions stimulates AKT activation. We previously discovered that oxyresveratrol inhibited inflammation via suppressing AKT phosphorylation,… read more here.
Keywords: akt activation; activation; tnf stimulated; oxyresveratrol ... See more keywords