Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.06.011
Abstract: Abstract Wedelolactone (WDL) is a natural compound derived from Chinese herbal medicine Eclipta prostrate L, and has been reported to exhibit various effects potentially beneficial for human health. However, the possible preventive effects of WDL… read more here.
Keywords: akt ampk; proliferation; wedelolactone; neointimal hyperplasia ... See more keywords
Gymnemic Acid Ameliorate Hyperglycemia Through PI3K/AKT and AMPK Mediated Signaling Pathway in T2DM Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b04931
Abstract: Gymnemic acid (GA) isolated from gymnema sylvestre (Retz.) Schult has been shown to display anti-diabetic activity, however the molecular mechanisms governing these effects are unclear. In this study, GA (40, 80 mg/kg/day) was evaluated by… read more here.
Keywords: gymnemic acid; akt ampk; pi3k akt; ampk mediated ... See more keywords
Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/9364364
Abstract: Excessive oxidative stress plays a critical role in the progression of various diseases. Recently, we showed that Terminalia bellirica (Gaertn.) Roxb. extract (TBE) inhibits inflammatory response and reactive oxygen species (ROS) production in THP-1 macrophages.… read more here.
Keywords: expression; akt ampk; oxidative stress;
AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.720173
Abstract: HIF-1α is a key factor promoting the development of hepatocellular carcinoma (HCC). As well, AKT-AMPKα-mTOR signaling is a promising target for cancer therapy. Yet, the AKT-AMPKα-mTOR-dependent activation of HIF-1α has not been studied in livers… read more here.
Keywords: ampk mtor; activation; akt ampk; hif ... See more keywords
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.921394
Abstract: Stroke remains one of the leading reasons of mortality and physical disability worldwide. The treatment of cerebral ischemic stroke faces challenges, partly due to a lack of effective treatments. In this study, we demonstrated that… read more here.
Keywords: mtor phosphorylation; autophagy via; ampk mtor; suppressing autophagy ... See more keywords