Effects of microRNA‐206 and its target gene IGF‐1 on sevoflurane‐induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26248
Abstract: The study aims to explore the effects of microRNA‐206 (miR‐206) targeting IGF‐1 on the activation of hippocampal astrocytes in aged rats induced by sevoflurane through the PI3K/AKT/CREB signaling pathway. Wistar rats and astrocytes were divided… read more here.
Keywords: akt creb; mir 206; pi3k akt; activation hippocampal ... See more keywords
Icariin promotes mouse Leydig cell testosterone synthesis via the Esr1/Src/Akt/Creb/Sf-1 pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2022.115969
Abstract: Icariin (ICA), extracted from Epimedium, is a flavonoid used in traditional Chinese medicine. Di(2-ethylhexyl) phthalate (DEHP) is a phthalate used in commercial products as a plasticizer that can influence the human endocrine and reproduction system.… read more here.
Keywords: testosterone synthesis; akt creb; leydig; creb ... See more keywords
7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer’s Disease Model Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Agricultural and Food Chemistry"
DOI: 10.1021/acs.jafc.2c02140
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and is clinically characterized by the impairment of memory and cognition. Accumulation of β-amyloid (Aβ) in the brain is considered as a key process in the development… read more here.
Keywords: pi3k akt; alzheimer disease; creb bdnf; synaptic loss ... See more keywords
Dammarane-Type Saponins from Gynostemma pentaphyllum prevent hypoxia-induced neural injury through activation of ERK, Akt and CREB pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b06659
Abstract: Gynostemma pentaphyllum possesses the neuroprotective bioactivity. However, the effect of gypenosides on the hypoxia-induced neural damage remains obscure. In this study, Gyp, the active fraction extracted from G. pentaphyllum, and its bioactive compounds as well… read more here.
Keywords: akt creb; erk akt; gynostemma pentaphyllum; injury ... See more keywords
Ginkgolide B promotes oligodendrocyte precursor cell differentiation and survival via Akt/CREB/bcl-2 signaling pathway after white matter lesion
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DOI: 10.1177/1535370221989955
Abstract: White matter lesion (WML) is caused by chronic cerebral hypoperfusion, which are usually associated with cognitive impairment. Evidence from recent studies has shown that ginkgolide B has a neuroprotective effect that could be beneficial for… read more here.
Keywords: akt creb; ginkgolide promotes; matter lesion; oligodendrocyte precursor ... See more keywords
Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1014497
Abstract: Gintonin, a glycolipid protein conjugated with lysophosphatidic acid (LPA), is a newly identified compound extracted from Korean ginseng. LPA receptor isotypes exhibit high affinity for gintonin and mediate intracellular calcium signaling in various animal cell… read more here.
Keywords: dendritic growth; gintonin; striatal neurons; akt creb ... See more keywords