Brucein D imparts a growth inhibitory effect in multiple myeloma cells by abrogating the Akt‐driven signaling pathway
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DOI: 10.1002/iub.2684
Abstract: The Akt signaling pathway is an oncogenic cascade activated in the bone marrow microenvironment of multiple myeloma (MM) cells and contributes to their uncontrolled proliferation. Abrogation of Akt signaling has been presented as one of… read more here.
Keywords: akt driven; signaling pathway; effect; myeloma cells ... See more keywords
A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
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DOI: 10.1158/1078-0432.ccr-22-0611
Abstract: Abstract Purpose: Therapy resistance and fatal disease progression in glioblastoma are thought to result from the dynamics of intra-tumor heterogeneity. This study aimed at identifying and molecularly targeting tumor cells that can survive, adapt, and… read more here.
Keywords: akt driven; glioblastoma; progression; therapy ... See more keywords