Articles with "akt enos" as a keyword



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Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway

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Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7621

Abstract: Random skin flaps are often used in reconstruction operations. However, flap necrosis is still a common postoperative complication. Here, we investigated whether berberine (C20H19NO5, BBR), a drug with antioxidant activity, improves the survival rate of… read more here.

Keywords: pi3k akt; akt enos; berberine promotes; skin flaps ... See more keywords
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Mannoproteins from Saccharomyces cerevisiae stimulate angiogenesis by promoting the akt-eNOS signaling pathway in endothelial cells.

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Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.09.069

Abstract: Mannoproteins (MPs) are a major component of yeast cell walls and consist of high levels of mannose in covalent complexes with proteins. MPs complexly enhance the immune system. We previously isolated a mutant yeast, K48L3,… read more here.

Keywords: saccharomyces cerevisiae; angiogenesis; cerevisiae stimulate; signaling pathway ... See more keywords
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Buxuhuayu Decoction Accelerates Angiogenesis by Activating the PI3K-Akt-eNOS Signalling Pathway in a Streptozotocin-Induced Diabetic Ulcer Rat Model.

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Published in 2021 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2021.113824

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Buxuhuayu decoction (BXHYD) has been frequently used to treat patients with diabetic ulcers (DUs), without notable adverse reactions. However, the related molecular mechanism remains unelucidated. AIM OF THE STUDY This study assessed the… read more here.

Keywords: buxuhuayu decoction; pi3k akt; bxhyd; signalling pathway ... See more keywords
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Modulation of the VEGF/AKT/eNOS signaling pathway to regulate liver angiogenesis to explore the anti-hepatic fibrosis mechanism of curcumol.

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Published in 2021 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2021.114480

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Curcuma is a common Chinese herbal medicine that is used in the clinical treatment of chronic liver disease. Studies have found that curcumol is the main active ingredient of curcuma and has good… read more here.

Keywords: vegf akt; mechanism; group; liver ... See more keywords
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Crocetin restores diabetic endothelial progenitor cell dysfunction by enhancing NO bioavailability via regulation of PI3K/AKT‐eNOS and ROS pathways

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Published in 2017 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.05.021

Abstract: Aims: Endothelial progenitor cell (EPC) dysfunction underlies a critical risk factor in diabetic vascular complications due to function defect in restoring endothelium injury. Crocetin has attracted increasing attention in several vascular‐related diseases. In present study,… read more here.

Keywords: dysfunction; crocetin; pi3k akt; akt enos ... See more keywords
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Long-term co-administration of sodium nitrite and sodium hydrosulfide inhibits hepatic gluconeogenesis in male type 2 diabetic rats: Role of PI3K-Akt-eNOS pathway.

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Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118770

Abstract: OBJECTIVE A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration… read more here.

Keywords: gluconeogenesis; administration; nitrite nash; sodium ... See more keywords
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Resveratrol Mitigates High-Fat Diet–Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway

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Published in 2018 at "Journal of Cardiovascular Pharmacology"

DOI: 10.1097/fjc.0000000000000621

Abstract: Abstract: We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for… read more here.

Keywords: rsv; sirt1 pathway; vascular dysfunction; induced vascular ... See more keywords
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Hydromorphine postconditioning protects isolated rat heart against ischemia‐reperfusion injury via activating P13K/Akt/eNOS signaling

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Published in 2018 at "Cardiovascular Therapeutics"

DOI: 10.1111/1755-5922.12481

Abstract: INTRODUCTION Myocardial ischemia/reperfusion injury (myocardial I/R injury) has a high disability rate and mortality. Novel treatments for myocardial I/R injury are necessary. AIM In order to explore the protective effect of hydromorphine on myocardial I/R… read more here.

Keywords: hydromorphine; reperfusion injury; ischemia reperfusion; akt enos ... See more keywords
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Endothelial S1pr1 regulates pressure overload‐induced cardiac remodelling through AKT‐eNOS pathway

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Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14900

Abstract: Cardiac vascular microenvironment is crucial for cardiac remodelling during the process of heart failure. Sphingosine 1‐phosphate (S1P) tightly regulates vascular homeostasis via its receptor, S1pr1. We therefore hypothesize that endothelial S1pr1 might be involved in… read more here.

Keywords: cardiac remodelling; enos pathway; heart failure; s1pr1 ... See more keywords
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Aliskiren Improved the Endothelial Repair Capacity of Endothelial Progenitor Cells from Patients with Hypertension via the Tie2/PI3k/Akt/eNOS Signalling Pathway

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Published in 2020 at "Cardiology Research and Practice"

DOI: 10.1155/2020/6534512

Abstract: Background Studies show that aliskiren exerts favourable effects not only on endothelial progenitor cells (EPCs) but also on endothelial function. However, the mechanism of the favourable effect of aliskiren on EPCs from patients with hypertension… read more here.

Keywords: tie2; signalling pathway; endothelial progenitor; hypertension ... See more keywords
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Exogenous Hydrogen Sulfide Activates PI3K/Akt/eNOS Pathway to Improve Replicative Senescence in Human Umbilical Vein Endothelial Cells

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Published in 2023 at "Cardiology Research and Practice"

DOI: 10.1155/2023/7296874

Abstract: Background Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling plays an important role in… read more here.

Keywords: pi3k akt; akt enos; endothelial cells; senescence ... See more keywords