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Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7621
Abstract: Random skin flaps are often used in reconstruction operations. However, flap necrosis is still a common postoperative complication. Here, we investigated whether berberine (C20H19NO5, BBR), a drug with antioxidant activity, improves the survival rate of…
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Keywords:
pi3k akt;
akt enos;
berberine promotes;
skin flaps ... See more keywords
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Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.069
Abstract: Mannoproteins (MPs) are a major component of yeast cell walls and consist of high levels of mannose in covalent complexes with proteins. MPs complexly enhance the immune system. We previously isolated a mutant yeast, K48L3,…
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Keywords:
saccharomyces cerevisiae;
angiogenesis;
cerevisiae stimulate;
signaling pathway ... See more keywords
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Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113824
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Buxuhuayu decoction (BXHYD) has been frequently used to treat patients with diabetic ulcers (DUs), without notable adverse reactions. However, the related molecular mechanism remains unelucidated. AIM OF THE STUDY This study assessed the…
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Keywords:
buxuhuayu decoction;
pi3k akt;
bxhyd;
signalling pathway ... See more keywords
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Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114480
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Curcuma is a common Chinese herbal medicine that is used in the clinical treatment of chronic liver disease. Studies have found that curcumol is the main active ingredient of curcuma and has good…
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Keywords:
vegf akt;
mechanism;
group;
liver ... See more keywords
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Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.05.021
Abstract: Aims: Endothelial progenitor cell (EPC) dysfunction underlies a critical risk factor in diabetic vascular complications due to function defect in restoring endothelium injury. Crocetin has attracted increasing attention in several vascular‐related diseases. In present study,…
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Keywords:
dysfunction;
crocetin;
pi3k akt;
akt enos ... See more keywords
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Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118770
Abstract: OBJECTIVE A deficiency in hydrogen sulfide (H2S) and nitric oxide (NO) contributes to the development of type 2 diabetes (T2D). An inhibitory effect on liver gluconeogenesis has been reported in rats with T2D with co-administration…
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Keywords:
gluconeogenesis;
administration;
nitrite nash;
sodium ... See more keywords
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1
Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000621
Abstract: Abstract: We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for…
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Keywords:
rsv;
sirt1 pathway;
vascular dysfunction;
induced vascular ... See more keywords
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Published in 2018 at "Cardiovascular Therapeutics"
DOI: 10.1111/1755-5922.12481
Abstract: INTRODUCTION Myocardial ischemia/reperfusion injury (myocardial I/R injury) has a high disability rate and mortality. Novel treatments for myocardial I/R injury are necessary. AIM In order to explore the protective effect of hydromorphine on myocardial I/R…
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Keywords:
hydromorphine;
reperfusion injury;
ischemia reperfusion;
akt enos ... See more keywords
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Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14900
Abstract: Cardiac vascular microenvironment is crucial for cardiac remodelling during the process of heart failure. Sphingosine 1‐phosphate (S1P) tightly regulates vascular homeostasis via its receptor, S1pr1. We therefore hypothesize that endothelial S1pr1 might be involved in…
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Keywords:
cardiac remodelling;
enos pathway;
heart failure;
s1pr1 ... See more keywords
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1
Published in 2020 at "Cardiology Research and Practice"
DOI: 10.1155/2020/6534512
Abstract: Background Studies show that aliskiren exerts favourable effects not only on endothelial progenitor cells (EPCs) but also on endothelial function. However, the mechanism of the favourable effect of aliskiren on EPCs from patients with hypertension…
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Keywords:
tie2;
signalling pathway;
endothelial progenitor;
hypertension ... See more keywords
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Published in 2023 at "Cardiology Research and Practice"
DOI: 10.1155/2023/7296874
Abstract: Background Endothelial cell senescence is one of the key mechanistic factors in the pathogenesis of atherosclerosis. In terms of molecules, the phosphatidylinositol 3-kinase/protein kinase B/endothelial nitric oxide synthase (PI3K/Akt/eNOS) signaling plays an important role in…
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Keywords:
pi3k akt;
akt enos;
endothelial cells;
senescence ... See more keywords