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   Articles with "akt erk" as a keyword



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Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart

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recommendations! Published in 2017 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.25947

Abstract: Cyclophilin D (CypD) is a mitochondrial chaperone that regulates the mitochondrial permeability transition pore. Metabolically, deletion of Ppif (the gene encoding CypD) in mice is associated with elevated levels of mitochondrial matrix Ca2+ that leads… read more here.

Keywords: akt; heart; cyclophilin; ppif ... See more keywords
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PDGF‐AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia

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recommendations! Published in 2022 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30345

Abstract: Testes control the development of male reproductive system. The testicular interstitial Leydig cells (Leydig cells) synthesize testosterone for promoting spermatogenesis and secondary sexual characteristics. Type A platelet‐derived growth factor (PDGF‐AA) is one of the most… read more here.

Keywords: growth; leydig; leydig cell; akt erk ... See more keywords

The tyrosine phosphatase SHP2 promotes proliferation and oxaliplatin resistance of colon cancer cells through AKT and ERK.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.05.068

Abstract: The SH2 domain-containing phosphatase 2 (SHP2) is a widely expressed protein tyrosine phosphatase, and it is proposed to act as an oncogenic protein. SHP2 is also engaged in drug resistance of a variety of cancers.… read more here.

Keywords: shp2; akt erk; proliferation; resistance ... See more keywords
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AKT and ERK dual inhibitors: The way forward?

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2019.05.025

Abstract: Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth, proliferation, survival, mobility and invasion. Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway is also an important mitogenic signaling pathway involved in various cellular progresses. AKT, also named… read more here.

Keywords: kinase; akt erk; way forward; inhibitors way ... See more keywords
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Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion.

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recommendations! Published in 2019 at "Microbes and infection"

DOI: 10.1016/j.micinf.2019.06.003

Abstract: Cell invasion by Trypanosoma cruzi extracellular amastigotes involves different signaling pathways to induce phagocytosis-like mechanisms. Previous works indicated that PI3K/Akt, Src and Erk might be involved in EA invasion; however, participation of these molecules in… read more here.

Keywords: akt; invasion; akt erk; pi3k akt ... See more keywords
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Lmod3 promotes myoblast differentiation and proliferation via the AKT and ERK pathways

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recommendations! Published in 2020 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2020.112297

Abstract: Abstract Mutations in the Lmod3 gene have been identified as a genetic cause of nemaline myopathy. However, the mechanism underlying this disease and the function of Lmod3 remain largely unknown. In this study, we found… read more here.

Keywords: differentiation; myoblast differentiation; proliferation; erk pathways ... See more keywords
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INTS6 promotes colorectal cancer progression by activating of AKT and ERK signaling.

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recommendations! Published in 2021 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2021.112826

Abstract: INTS6 (integrator complex subunit 6) has been reported as a tumor suppressor in many cancers. However, the expression and biological function of INTS6 in colorectal cancer (CRC) has not been investigated yet. In this study,… read more here.

Keywords: akt erk; colorectal cancer; ints6; crc ... See more keywords
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Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism.

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recommendations! Published in 2022 at "Journal of food biochemistry"

DOI: 10.1111/jfbc.14233

Abstract: Administration of Piper retrofractum extract (PRE) has been reported to alleviate edema, but the mechanism underlying this effect is unknown. Promotion of lymphangiogenesis is known to improve lymphedema, but the effect of PRE on lymphangiogenesis… read more here.

Keywords: piperine; lymphangiogenesis; piperine promote; promote lymphangiogenesis ... See more keywords
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miR-100-5p Promotes Epidermal Stem Cell Proliferation through Targeting MTMR3 to Activate PIP3/AKT and ERK Signaling Pathways

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recommendations! Published in 2022 at "Stem Cells International"

DOI: 10.1155/2022/1474273

Abstract: Skin epidermal stem cells (EpSCs) play a critical role in wound healing and are ideal seed cells for skin tissue engineering. Exosomes from human adipose-derived stem cells (ADSC-Exos) promote human EpSC proliferation, but the underlying… read more here.

Keywords: epscs; proliferation; adsc exos; mir 100 ... See more keywords
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Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways

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recommendations! Published in 2019 at "Virology Journal"

DOI: 10.1186/s12985-019-1266-x

Abstract: BackgroundPatchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial… read more here.

Keywords: cellular pi3k; akt erk; inhibition; pi3k akt ... See more keywords
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Cinnamomi Ramulus inhibits the growth of colon cancer cells via Akt/ERK signaling pathways

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recommendations! Published in 2022 at "Chinese Medicine"

DOI: 10.1186/s13020-022-00588-6

Abstract: Background Colon cancer (CC) ranks the second highest mortality rate among malignant tumors worldwide, and the current mainstream treatment regimens are not very effective. The unique efficacy of Chinese herb medicine (CHM) for cancer has… read more here.

Keywords: cancer; erk signaling; medicine; akt erk ... See more keywords