Maduramicin induces cardiac muscle cell death by the ROS‐dependent PTEN/Akt–Erk1/2 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27830
Abstract: Maduramicin (Mad), a polyether ionophore antibiotic, has been reported to be toxic to animals and humans because of being used at high doses or for long time, resulting in heart failure. However, the toxic mechanism… read more here.
Keywords: akt erk1; cardiac muscle; cell death; mad induced ... See more keywords
DRm217 attenuates myocardial ischemia‐reperfusion injury via stabilizing plasma membrane Na+‐K+‐ATPase, inhibiting Na+‐K+‐ATPase/ROS pathway and activating PI3K/Akt and ERK1/2
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.04.030
Abstract: ABSTRACT Na+‐K+‐ATPase has close relationship with myocardial ischemia/reperfusion (IR) injury. Activation of Na+‐K+‐ATPase with its DR region specific antibody produces cardioprotective effect. In this study, we aimed to explore whether DRm217, a proved DR region… read more here.
Keywords: akt erk1; atpase; myocardial ischemia; drm217 ... See more keywords
COMPOUND 21 STIMULATES THE ACTIVATION OF AKT AND ERK1/2 IN MOUSE ADIPOSE TISSUE IN VIVO
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000838480.81802.e1
Abstract: Objective: To analyze signaling events triggered by in vivo stimulation of the AT2 receptor. Design and method: Male B57Bl/6 mice were used as model at the age of 3 month. Mice were subjected to a… read more here.
Keywords: akt erk1; adipose tissue; erk1; activation akt ... See more keywords
Neuregulin1 acts as a suppressor in human lung adenocarcinoma via AKT and ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2018.05.175
Abstract: Background Neuregulin1 (NRG1) is critical signaling protein that mediates the activation of downstream signaling pathways associated with malignancies. Multiple gene fusions related to NRG1 have been found in lung cancer. However, the underlying role NRG1… read more here.
Keywords: lung adenocarcinoma; akt erk1; nrg1; human lung ... See more keywords
Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) Plays an Oncogenic Role in Thyroid Carcinoma by Activating the AKT and ERK1/2 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230118111745
Abstract: BACKGROUND Thyroid carcinoma (TC) is a common malignant tumor in human and its incidence has been increasing in recent years. Studies have shown that receptor type protein tyrosine phosphatase epsilon (PTPRE) is a key regulator… read more here.
Keywords: thyroid carcinoma; signaling pathway; erk1 signaling; role ... See more keywords
Toll-Like Receptor 4 Activation Prevents Rat Cardiac Fibroblast Death Induced by Simulated Ischemia/Reperfusion
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.660197
Abstract: Death of cardiac fibroblasts (CFs) by ischemia/reperfusion (I/R) has major implications for cardiac wound healing. In in vivo models of myocardial infarction, toll-like receptor 4 (TLR4) activation has been reported as a cardioprotector; however, it… read more here.
Keywords: akt erk1; death; ischemia; activation ... See more keywords