miR-29a-3p mitigates the development of osteosarcoma through modulating IGF1 mediated PI3k/Akt/FOXO3 pathway by activating autophagy
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DOI: 10.1080/15384101.2022.2078614
Abstract: ABSTRACT Osteosarcoma (OS), occurring in mesenchymal tissues and with a high degree of malignancy, is most common in children and adolescents. At present, we intend to figure out the expression and functions of miR-29a-3p in… read more here.
Keywords: pi3k akt; igf1; akt foxo3; mir 29a ... See more keywords
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke.
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DOI: 10.1139/cjpp-2022-0341
Abstract: Autophagy has been implicated in stroke. Our previous study showed that the FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion (I/R). However, whether the Akt/FoxO3 signaling pathway plays a regulatory role in autophagy in… read more here.
Keywords: signaling pathway; oxidative stress; akt foxo3; foxo3 signaling ... See more keywords
Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression
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DOI: 10.3389/fonc.2022.924988
Abstract: Colorectal cancer (CRC) remains one of the most common malignancies worldwide and its mechanism is unclear. Polymeric immunoglobulin receptor (PIGR) which plays an important role in mucosal immunity is widely expressed in the mucosal epithelium… read more here.
Keywords: pigr; foxo3 axis; immunoglobulin receptor; polymeric immunoglobulin ... See more keywords