EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: In Vivo and In Vitro Rat Studies.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.0c00005
Abstract: Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of PTEN/Akt/FoxO3a pathway, which… read more here.
Keywords: inhibitor; pten akt; foxo3a pathway; cardiotoxicity ... See more keywords
Supplementing cultured human myotubes with hibernating bear serum results in increased protein content by modulating Akt/FOXO3a signaling
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263085
Abstract: Hibernating bears remain in their dens for 5–7 months during winter and survive without eating or drinking while staying inactive. However, they maintain their physical functions with minimal skeletal muscle atrophy and metabolic dysfunction. In… read more here.
Keywords: bear serum; muscle; akt foxo3a; hibernating bear ... See more keywords
PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076385
Abstract: Pulmonary arterial hypertension (PAH) is a group of severe, progressive, and debilitating diseases with limited therapeutic options. This study aimed to explore novel therapeutic targets in PAH through bioinformatics and experiments. Weighted gene co-expression network… read more here.
Keywords: arterial hypertension; akt foxo3a; pulmonary arterial; smooth muscle ... See more keywords