Akt as a target for cancer therapy: more is not always better (lessons from studies in mice)
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Cancer"
DOI: 10.1038/bjc.2017.153
Abstract: The PI3K/Akt signalling pathway is one of the most frequently altered signalling networks in human cancers and has become an attractive target in anticancer therapy. Several drugs targeting this pathway are currently in different phases… read more here.
Keywords: akt; target; akt isoforms; cancer ... See more keywords
Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.
Sign Up to like & getrecommendations! Published in 2023 at "Reproduction"
DOI: 10.1530/rep-22-0353
Abstract: Apoptosis and cell survival regulation are crucial processes during the estrous cycle to prepare a receptive uterus during implantation for successful recognition of pregnancy. PI3K/AKT signaling has a crucial role during gestation and AKT isoforms… read more here.
Keywords: fertility; gland development; estrous cyclicity; akt isoforms ... See more keywords
AKT Isoforms Interplay in High-Grade Serous Ovarian Cancer Prognosis and Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14020304
Abstract: Simple Summary New therapeutical strategies are needed to improve survival in high-grade serous ovarian cancer (HGSOC) patients. AKT inhibitors are promising agents able to act in synergy with PARP inhibitors and platinum-based therapies, but the… read more here.
Keywords: high grade; grade serous; ovarian cancer; serous ovarian ... See more keywords
Sevoflurane Modulates AKT Isoforms in Triple Negative Breast Cancer Cells. An Experimental Study.
Sign Up to like & getrecommendations! Published in 2021 at "Current issues in molecular biology"
DOI: 10.3390/cimb43010022
Abstract: (1) Background: Triple negative breast cancer (TNBC) is a highly aggressive tumor, associated with high rates of early distant recurrence and short survival times, and treatment may require surgery, and thus anesthesia. The effects of… read more here.
Keywords: negative breast; breast cancer; akt isoforms; cancer ... See more keywords
AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.30640
Abstract: AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its direct role has not been… read more here.
Keywords: roles synaptic; akt isoforms; expression; synaptic plasticity ... See more keywords
Prognostic value of AKT isoforms in non-small cell lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.36.20220138
Abstract: Dear Editor, Lung cancer is one of the most prevalent cancers in the world and has a high mortality rate. Lung cancer patients often have a poor prognosis, with a five-year survival rate of only… read more here.
Keywords: lung cancer; lung; akt isoforms; cancer ... See more keywords