Protective effect of Sulforaphane against Arsenic-induced hepatotoxicity in rats: Role of PI3K/Akt-mediated Nrf2 signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.295
Abstract: Background Industrial and agricultural growths in recent years has resulted in the extreme discharge of arsenic into the environment, making arsenic toxicity a major worldwide concern. Oxidative stress is considered the primary mechanism for arsenic… read more here.
Keywords: mediated nrf2; akt; pi3k akt; arsenic induced ... See more keywords
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase
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DOI: 10.1126/science.aau3903
Abstract: Akt produces reducing power The protein kinase Akt provides a link from growth factors to the production of metabolic reducing power within the cell. Hoxhaj et al. discovered that Akt directly phosphorylates nicotinamide adenine dinucleotide… read more here.
Keywords: akt; kinase; akt mediated; nad kinase ... See more keywords
Distinct Roles of CK2- and AKT-Mediated NF-κB Phosphorylations in Clasmatodendrosis (Autophagic Astroglial Death) within the Hippocampus of Chronic Epilepsy Rats
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DOI: 10.3390/antiox12051020
Abstract: The downregulation of glutathione peroxidase-1 (GPx1) plays a role in clasmatodendrosis (an autophagic astroglial death) in the hippocampus of chronic epilepsy rats. Furthermore, N-acetylcysteine (NAC, a GSH precursor) restores GPx1 expression in clasmatodendritic astrocytes and… read more here.
Keywords: akt mediated; clasmatodendrosis autophagic; astroglial death; autophagic astroglial ... See more keywords