Fingolimod ameliorates chronic experimental autoimmune neuritis by modulating inflammatory cytokines and Akt/mTOR/NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2965
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated disease that targets the myelin sheaths of the peripheral nerves. Fingolimod is a sphingosine 1 phosphate (S1P) receptor antagonist with a high affinity for S1P receptors through… read more here.
Keywords: autoimmune neuritis; chronic experimental; experimental autoimmune; ameliorates chronic ... See more keywords
LncRNA‐LOC101928316 contributes to gastric cancer progression through regulating PI3K‐Akt‐mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2165
Abstract: Long noncoding RNA (lncRNA) has played the important function in regulation of various biological processes and in diagnostic value has been widely appreciated. In the present study, we have found that LOC101928316 was significantly downregulated… read more here.
Keywords: gastric cancer; mtor signaling; pi3k akt; signaling pathway ... See more keywords
Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2723
Abstract: Hepatocellular carcinoma (HCC) is a devastating and highly metastatic cancer worldwide. Metformin (MET) is the priority drug for treatment of type 2 diabetes; however, it possesses multiple biological effects like anticancer and hepatoprotective activity. Herein,… read more here.
Keywords: apoptosis; pi3k akt; apoptosis autophagy; aloin met ... See more keywords
Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mTOR signaling
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DOI: 10.1002/cbin.11218
Abstract: Protosappanin‐A (PrA) and oleanolic acid (OA), which are important effective ingredients isolated from Caesalpinia sappan L., exhibit therapeutic potential in multiple diseases. This study focused on exploring the mechanisms of PrA and OA function in… read more here.
Keywords: akt; injured podocytes; oleanolic acid; akt mtor ... See more keywords
PIK3CB promotes oesophageal cancer proliferation through the PI3K/AKT/mTOR signalling axis
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DOI: 10.1002/cbin.11847
Abstract: PIK3CB is abnormally expressed in various carcinomas and affects the proliferation, invasion and drug resistance of cancer cells. However, its role in oesophageal squamous cell carcinoma (ESCC) is still unclear. In this study, PIK3CB was… read more here.
Keywords: mtor signalling; pi3k akt; escc; pik3cb ... See more keywords
MYH9 is a novel cancer stem cell marker and prognostic indicator in esophageal cancer that promotes oncogenesis through the PI3K/AKT/mTOR axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11894
Abstract: MYH9 encodes the heavy chain of nonmuscle myosin IIA, a ubiquitously expressed cytoplasmic myosin that regulates the actin cytoskeleton, cell migration, cell polarization, and signal transduction in cancer cells. Here, we investigated the role of… read more here.
Keywords: myh9; pi3k akt; cell; akt mtor ... See more keywords
Overexpression of TRIM32 promotes pancreatic β‐cell autophagic cell death through Akt/mTOR pathway under high glucose conditions
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11897
Abstract: Type 2 diabetes mellitus (T2DM) is a growing worldwide epidemic and is characterized by progressive pancreatic β‐cell dysfunction and insulin resistance. Tripartite motif protein 32 (TRIM32) belongs to the TRIM family protein and has been… read more here.
Keywords: cell; pancreatic cell; akt mtor; high glucose ... See more keywords
Chrysin promotes angiogenesis in rat hindlimb ischemia: Impact on PI3K/Akt/mTOR signaling pathway and autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21954
Abstract: Limb ischemia occurs due to obstruction of blood perfusion to lower limbs, a manifestation that is associated with peripheral artery disease (PAD). Angiogenesis is important for adequate oxygen delivery. The present study investigated a potential… read more here.
Keywords: akt mtor; mtor; pi3k akt; chrysin ... See more keywords
Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory subunit 2
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DOI: 10.1002/ddr.21978
Abstract: Replication protein A 3 (RPA3) is a significant component of replication protein A and has been documented to function as an oncogene in several types of cancers. However, the role and underlying mechanism of RPA3… read more here.
Keywords: cell; mtor signaling; akt mtor; cisplatin sensitivity ... See more keywords
Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF‐κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22597
Abstract: Ginsenoside Rh2 is a primary bioactive compound obtained from ginseng that indicated anticancer activities against several malignant tumors. However, previous studies have reported little about the inhibitory effect of Rh2 on osteosarcoma (OS). This study… read more here.
Keywords: u20s cells; rh2; pi3k akt; migration ... See more keywords
l‐Asparaginase synergizes with etoposide via the PI3K/Akt/mTOR pathway in Epstein−Barr virus‐positive Burkitt lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23117
Abstract: Burkitt lymphoma (BL) is an aggressive Epstein−Barr virus (EBV)‐driven B‐cell lymphoma characterized by the translocation and rearrangement of the c‐Myc proto‐oncogene. High‐intensity multidrug chemotherapy regimens have a limited effect on the survival of refractory or… read more here.
Keywords: akt mtor; pi3k akt; burkitt lymphoma; epstein barr ... See more keywords