Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01944-9
Abstract: Deregulated activity of protein kinase B/mammalian target of rapamycin complex-1 (Akt/mTORC1) incites crucial pathological characteristics of diabetic nephropathy. The acyclic monoterpene geraniol has been recently reported to possess antidiabetic effects; however, its potential renoprotective effect… read more here.
Keywords: mtorc1 pathway; pten akt; diabetic nephropathy; akt mtorc1 ... See more keywords
Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.04.007
Abstract: Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation of distinct oncogenic mechanisms. In homeostatic and… read more here.
Keywords: akt mtorc1; catenin pi3k; wnt catenin; pi3k akt ... See more keywords
SLC6A14 Depletion Contributes to Amino Acid Starvation to Suppress EMT-Induced Metastasis in Gastric Cancer by Perturbing the PI3K/AKT/mTORC1 Pathway
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DOI: 10.1155/2022/7850658
Abstract: Metastasis is the main obstacle for the treatment of gastric cancer (GC), leading to low survival rate and adverse outcomes in CG patients. SLC6A14, a general amino acid transporter, can import all the essential amino… read more here.
Keywords: metastasis; pi3k akt; akt mtorc1; amino acid ... See more keywords
Abstract B092: Molecular aberrations of the PI3K-AKT-mTORC1/C2 pathway in ovarian cancers: a strategy for targeted therapy
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b092
Abstract: Background: Ovarian cancer is the most lethal gynecologic cancer worldwide since most patients are diagnosed at an advanced stage of the disease. Genetic alterations of the PI3K-AKT-mTORC1/C2 pathway in ovarian cancer (OC) are characteristically abundant… read more here.
Keywords: inhibitor; mtorc1 pathway; pi3k akt; cancer ... See more keywords
Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-018-0583-4
Abstract: Glioblastoma (GB) is the most frequent primary brain tumor in adults with a dismal prognosis despite aggressive treatment including surgical resection, radiotherapy and chemotherapy with the alkylating agent temozolomide. Thus far, the successful implementation of… read more here.
Keywords: mtorc1 signaling; glioblastoma; antibody nimotuzumab; akt mtorc1 ... See more keywords
Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.650816
Abstract: Psoriasis is a chronic proliferative skin disorder characterised by abnormal epidermal differentiation. The Fuzhenghefuzhiyang (FZHFZY) formula created by Chuanjian Lu, a master of Chinese medicine in dermatology, has been external used in the Guangdong Provincial… read more here.
Keywords: fzhfzy; epidermal differentiation; differentiation; psoriasis ... See more keywords
C1orf74 positively regulates the EGFR/AKT/mTORC1 signaling in lung adenocarcinoma cells
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DOI: 10.7717/peerj.13908
Abstract: Background Lung adenocarcinoma (LUAD) is a major type of lung cancer with poor prognosis and low 5-year survival rate, which urgently needs further investigation in order to elucidate its mechanisms completely and discover novel therapeutic… read more here.
Keywords: egfr akt; mtorc1 signaling; luad; akt mtorc1 ... See more keywords