Targeting PI3Kγ/AKT Pathway Remodels LC3‐Associated Phagocytosis Induced Immunosuppression After Radiofrequency Ablation
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DOI: 10.1002/advs.202102182
Abstract: Residual tumors after insufficient radiofrequency ablation (IRFA) shows accelerated progression and anti‐PD‐1 resistance. It is also reported that macrophages infiltrating into residual tumors leads to anti‐PD‐1 resistance. Elements of autophagy have been detected to conjugate… read more here.
Keywords: akt pathway; lc3 associated; residual tumors; pi3k akt ... See more keywords
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2711
Abstract: AIMS Diabetic kidney disease (DKD) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this work was to evaluate the relevance of PI3K/Akt pathway polymorphisms and… read more here.
Keywords: pi3k akt; dkd; meta analysis; akt pathway ... See more keywords
LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27704
Abstract: LncRNAs exhibit crucial roles in various pathological diseases, including hepatocellular carcinoma (HCC). Therefore, it is significant to recognize the dysregulated lncRNAs in HCC progression. Recently, LINC01133 has been identified in several tumors. However, the biological… read more here.
Keywords: hcc; linc01133; pi3k akt; progression ... See more keywords
MicroRNA‐598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29453
Abstract: Recently, microRNAs (miRNAs) receive more attention due to their role in the pathogenesis of malignancies. Retinoblastoma (RB) is the most serious and harmful malignant tumor in infants and young children with eye diseases, which often… read more here.
Keywords: mir 598; viability metastasis; cell; akt pathway ... See more keywords
The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26620
Abstract: Despite significant advances in treatment modalities, millions of cancer‐related deaths continue to occur annually, often as a consequence of developing resistance against the range of available chemotherapeutic drugs. Furthermore, available anti‐cancer chemotherapeutic agents show limited… read more here.
Keywords: treatment; pi3k akt; cancer; anti cancer ... See more keywords
LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01788-y
Abstract: Acute myeloid leukemia is an aggressive myeloid malignancy, characterized by rapid cellular proliferation and generally high mortality. Due to the lack of a complete understanding of AML, its clinical outcomes are still not satisfactory. In… read more here.
Keywords: hcp5; pathway activation; pi3k akt; psmb8 ... See more keywords
Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-00945-9
Abstract: Spontaneous intracerebral hemorrhage (ICH) is a clinical challenge with high disability and lacks an effective treatment. miR-29a strongly expressed in the brain has been implicated in various neurological disorders. In this study, we investigated the… read more here.
Keywords: outgrowth neurological; mir 29a; outgrowth; pi3k akt ... See more keywords
Cyanidin-3-O-Glucoside Attenuates Lipopolysaccharide-Induced Inflammation in Human Corneal Epithelial Cells by Inducing Let-7b-5p-Mediated HMGA2/PI3K/Akt Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01194-0
Abstract: The bacterial keratitis causes viability loss and apoptosis in the corneal epithelial cells (CECs). The cyanidin-3-O-glucoside (C3G) benefits visual system and also possess anti-bacterial and anti-inflammatory potentials. In the current study, the effects of C3G… read more here.
Keywords: hmga2 pi3k; inflammation; pi3k akt; let ... See more keywords
Wikstromol from Wikstroemia indica induces apoptosis and suppresses migration of MDA-MB-231 cells via inhibiting PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-020-01447-0
Abstract: Triple negative breast cancer (TNBC) is the most severe type of breast cancer due to the lack of specific targets and rapid metastasis, which result in the poor prognosis. Recently, phosphatidylinositol 3-kinase (PI3K)/Akt pathway has… read more here.
Keywords: 231 cells; wikstroemia indica; wikstromol wikstroemia; mda 231 ... See more keywords
EDNRB Reverses Methylprednisolone-Mediated Decrease in Neural Progenitor Cell Viability via Regulating PI3K/Akt Pathway and lncRNA Expression
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DOI: 10.1007/s12031-019-01427-4
Abstract: Objective To investigate the functions and mechanisms of methylprednisolone (MP) through endothelin receptor B (EDNRB) on the cell proliferation of neural progenitor cells (NPCs) to regulate spinal cord injury. Methods Primary NPCs were isolated from… read more here.
Keywords: ednrb agonist; pi3k akt; pathway; expression ... See more keywords
Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02611-7
Abstract: Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity and mortality in aged population. Several transcription molecules, pathways, and molecular mechanisms such as oxidative stress, inflammation, autophagy, and immune system interact… read more here.
Keywords: alzheimer disease; pi3k; akt pathway; pi3k akt ... See more keywords