The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K–AKT pathway
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13701
Abstract: The significance of the prominent tumor suppressor gene for RAS protein activator‐like 1 (RASAL1) could be better understood by combined genetic, clinical, and functional studies. Here, we investigated the oncogenic and clinical impacts of genetic… read more here.
Keywords: cancer; rasal1 pten; akt pathway; rasal1 ... See more keywords
Targeting PI3Kγ/AKT Pathway Remodels LC3‐Associated Phagocytosis Induced Immunosuppression After Radiofrequency Ablation
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DOI: 10.1002/advs.202102182
Abstract: Residual tumors after insufficient radiofrequency ablation (IRFA) shows accelerated progression and anti‐PD‐1 resistance. It is also reported that macrophages infiltrating into residual tumors leads to anti‐PD‐1 resistance. Elements of autophagy have been detected to conjugate… read more here.
Keywords: akt pathway; lc3 associated; residual tumors; pi3k akt ... See more keywords
Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta-analysis.
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB life"
DOI: 10.1002/iub.2711
Abstract: AIMS Diabetic kidney disease (DKD) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this work was to evaluate the relevance of PI3K/Akt pathway polymorphisms and… read more here.
Keywords: pi3k akt; dkd; meta analysis; akt pathway ... See more keywords
DC09, Derivative of 3‐(2‐hydroxy‐5‐methoxyphenyl)‐1‐(5‐methylfuran‐2‐yl)prop‐2‐en‐1‐one Attenuates Nonalcoholic Fatty Liver Disease by Targeting PI3K/Akt Pathway: Insights From In‐Vivo Zebrafish Model and In‐Vitro HepG2 Cell
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70547
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disorder characterized by lipid accumulation, oxidative stress, and inflammation, leading to severe conditions such as nonalcoholic steatohepatitis, fibrosis, or hepatocellular carcinoma. A primary driver of NAFLD… read more here.
Keywords: nonalcoholic fatty; akt pathway; pathway; pi3k akt ... See more keywords
LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27704
Abstract: LncRNAs exhibit crucial roles in various pathological diseases, including hepatocellular carcinoma (HCC). Therefore, it is significant to recognize the dysregulated lncRNAs in HCC progression. Recently, LINC01133 has been identified in several tumors. However, the biological… read more here.
Keywords: hcc; linc01133; pi3k akt; progression ... See more keywords
MicroRNA‐598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29453
Abstract: Recently, microRNAs (miRNAs) receive more attention due to their role in the pathogenesis of malignancies. Retinoblastoma (RB) is the most serious and harmful malignant tumor in infants and young children with eye diseases, which often… read more here.
Keywords: mir 598; viability metastasis; cell; akt pathway ... See more keywords
The versatile role of curcumin in cancer prevention and treatment: A focus on PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26620
Abstract: Despite significant advances in treatment modalities, millions of cancer‐related deaths continue to occur annually, often as a consequence of developing resistance against the range of available chemotherapeutic drugs. Furthermore, available anti‐cancer chemotherapeutic agents show limited… read more here.
Keywords: treatment; pi3k akt; cancer; anti cancer ... See more keywords
MCM4 Promotes the Progression of Malignant Melanoma by Activating the PI3K/AKT Pathway
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DOI: 10.1002/tox.24433
Abstract: This study aims to elucidate the role of minichromosome maintenance protein 4 (MCM4) in malignant melanoma (MM) and explore the underlying mechanism. Initially, data from The Cancer Genome Atlas (TCGA) database and the Molecular Signature… read more here.
Keywords: malignant melanoma; akt pathway; activating pi3k; pi3k akt ... See more keywords
LncRNA HCP5 promotes LAML progression via PSMB8-mediated PI3K/AKT pathway activation
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01788-y
Abstract: Acute myeloid leukemia is an aggressive myeloid malignancy, characterized by rapid cellular proliferation and generally high mortality. Due to the lack of a complete understanding of AML, its clinical outcomes are still not satisfactory. In… read more here.
Keywords: hcp5; pathway activation; pi3k akt; psmb8 ... See more keywords
UBQLN4 promotes the proliferation and invasion of non-small cell lung cancer cell by regulating PI3K/AKT pathway
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DOI: 10.1007/s00432-024-05862-8
Abstract: Ubiquilin-4 (UBQLN4), a member of the ubiquilin family, has received limited attention in cancer research to date. Here, we investigated for the first time the functional role and mechanism of UBQLN4 in non-small cell lung… read more here.
Keywords: cancer; proliferation invasion; akt pathway; cell ... See more keywords
Elevated miR-29a Contributes to Axonal Outgrowth and Neurological Recovery After Intracerebral Hemorrhage via Targeting PTEN/PI3K/Akt Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-00945-9
Abstract: Spontaneous intracerebral hemorrhage (ICH) is a clinical challenge with high disability and lacks an effective treatment. miR-29a strongly expressed in the brain has been implicated in various neurological disorders. In this study, we investigated the… read more here.
Keywords: outgrowth neurological; mir 29a; outgrowth; pi3k akt ... See more keywords