Metformin accelerate wound healing by Akt phosphorylation of gingival fibroblast in insulin-resistant prediabetes mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of periodontology"
DOI: 10.1002/jper.21-0362
Abstract: BACKGROUND This study aimed to investigate the effects of metformin on gingival wound healing in insulin-resistant prediabetes. METHODS C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for 10 weeks; half of the… read more here.
Keywords: gingival; wound healing; akt phosphorylation; insulin resistant ... See more keywords
CaMKII and Kalirin, a Rac1-GEF, regulate Akt phosphorylation involved in contraction-induced glucose uptake in skeletal muscle cells.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.152
Abstract: Rac1 plays an important role in contraction-stimulated muscle glucose uptake, but the mechanism is not fully elucidated. We previously identified Rac1-dependent activation of Akt played a partial role in contraction-stimulated GLUT4 translocation to the cell… read more here.
Keywords: muscle; glucose uptake; akt phosphorylation; rac1 ... See more keywords
Bombyxin/Akt signaling in relation to the embryonic diapause process of the silkworm, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2019.04.007
Abstract: Our previous study showed that phosphorylation of glycogen synthase kinase (GSK)-3β is related to the embryonic diapause process in Bombyx. However, the upstream signaling pathway was not clearly understood. In the present study, we examined… read more here.
Keywords: akt phosphorylation; diapause process; diapause; phosphorylation ... See more keywords
Positive feedback effect of PGE2 on cyclooxygenase‐2 expression is mediated by inhibition of Akt phosphorylation in human follicular dendritic cell‐like cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.04.004
Abstract: HighlightsPGE2, PGF2&agr;, and beraprost stimulate COX‐2 expression in human FDC‐like cells.PGE2 and beraprost, but not PGF2&agr;, reduce Akt phosphorylation in HK cells.PGE2 and beraprost, but not PGF2&agr;, induce COX‐2 expression by inhibiting Akt phosphorylation in… read more here.
Keywords: effect; expression; akt phosphorylation; pgf2 agr ... See more keywords
Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein Kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3-Kinase/Akt Phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00592
Abstract: Sixty palmatine (PMT) derivatives were synthesized and evaluated for antiplatelet aggregation taking berberine as the lead, and the structure-activity relationship was first systematically described. Among them, compound 2v showed the best potency in reducing adenosine… read more here.
Keywords: antiplatelet aggregation; aggregation; kinase; akt phosphorylation ... See more keywords
Impaired Akt Phosphorylation in Monocytes of Patients with Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12521
Abstract: It has been proposed that the Akt kinase pathway provides a regulatory mechanism to limit the inflammatory response. We examined the activation of Akt upon lipopolysaccharide (LPS) challenge in monocytes of patients with rheumatoid arthritis… read more here.
Keywords: monocytes patients; akt phosphorylation; rheumatoid arthritis; activation ... See more keywords
ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0003
Abstract: The zinc finger protein 677 (ZNF677) belongs to the zinc finger protein family, which possesses transcription factor activity by binding sequence-specific DNA. Previous studies have reported its downregulated by promoter methylation in non-small cell lung… read more here.
Keywords: cancer; akt phosphorylation; znf677; thyroid cancer ... See more keywords
The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188963
Abstract: During development, a multi-potent group of cells known as the cranial neural crest (CNC) migrate to form craniofacial structures. Proper migration of these cells requires proteolysis of cell adhesion molecules, such as cadherins. In Xenopus… read more here.
Keywords: cnc migration; akt phosphorylation; migration; cranial neural ... See more keywords
Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9060219
Abstract: Polyphenols exert beneficial effects in type 2 diabetes mellitus (T2DM). However, their mechanism of action remains largely unknown. Endothelial Akt-kinase plays a key role in the pathogenesis of cardiovascular complications in T2DM and therefore the… read more here.
Keywords: polyphenols akt; activity features; akt phosphorylation; structure activity ... See more keywords