Astaxanthin inhibits hallmarks of cancer by targeting the PI3K/NF‐κΒ/STAT3 signalling axis in oral squamous cell carcinoma models
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2104
Abstract: Aberrant activation of the PI3K/Akt signalling pathway, a major driving force of diverse cellular processes has been implicated in tumour development and progression. Here, we report that astaxanthin (AXT), a potent antioxidant ketocarotenoid prevents cancer… read more here.
Keywords: cancer; signalling axis; akt signalling; pi3k akt ... See more keywords
Insulin Mediated Activation of PI3K/Akt Signalling Pathway Modifies the Proteomic Cargo of Extracellular Vesicles
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DOI: 10.1002/pmic.201600371
Abstract: Epidemiological studies suggest that diabetes and obesity increases the risk of colorectal cancer (CRC) and lowers the patient survival rate. An important attribute in diabetes and obesity is the presence of high levels of growth… read more here.
Keywords: pi3k; pi3k akt; evs secreted; signalling pathway ... See more keywords
Interleukin-15 inhibits adipogenic differentiation of cattle bone marrow-derived mesenchymal stem cells via regulating the crosstalk between signal transducer and activator of transcription 5A and Akt signalling.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.068
Abstract: Interleukin (IL)-15 is an important regulator of adipogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). This study was designed to clarify the underlying mechanism. BMSCs were obtained from Nanyang cattle and stimulated to differentiate… read more here.
Keywords: marrow derived; derived mesenchymal; adipogenic differentiation; akt signalling ... See more keywords
Tetramethylpyrazine alleviates diabetic nephropathy through the activation of Akt signalling pathway in rats.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172763
Abstract: In the whole world, the principal cause of end-stage renal disease is diabetic nephropathy (DN), which is one of the most relentless complications of diabetes. However, there is a shortfall of compelling DN treatments and… read more here.
Keywords: akt signalling; t2d rats; signalling pathway; diabetic nephropathy ... See more keywords
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
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DOI: 10.1038/s41388-021-02017-8
Abstract: ISG15 is an ubiquitin-like modifier that is associated with reduced survival rates in breast cancer patients. The mechanism by which ISG15 achieves this however remains elusive. We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta… read more here.
Keywords: basal breast; isgylation; egfr recycling; tumour progression ... See more keywords
ELABELA improves endothelial cell function via the ELA–APJ axis by activating the PI3K/Akt signalling pathway in HUVECs and EA.hy926 cells
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13382
Abstract: Destruction of endothelial cells (ECs) function is involved in the structural and functional pathophysiological processes of preeclampsia (PE). Vascular endothelial injury may pre‐exist for several years in women that develop PE and may pose increased… read more here.
Keywords: akt signalling; pi3k akt; ela apj; function ... See more keywords
Sulphur doped carbon dots enhance photodynamic therapy via PI3K/Akt signalling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Proliferation"
DOI: 10.1111/cpr.12821
Abstract: Photodynamic therapy (PDT) is a promising approach for cancer treatment, and the underlying signalling pathway changes has been carried out for studying the PDT mechanisms, but is majorly limited to organic photosensitizers (PSs). For the… read more here.
Keywords: photodynamic therapy; pi3k akt; signalling pathway; sulphur doped ... See more keywords
Integrin αvβ3‐Akt signalling plays a role in radioresistance of melanoma
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DOI: 10.1111/exd.14102
Abstract: Melanoma is a deadly type of skin cancer that is particularly difficult to treat owing to its resistance to radiation therapy. Here, we attempted to determine the key proteins responsible for melanoma radioresistance, with the… read more here.
Keywords: melanoma; irradiation; radioresistance; integrin akt ... See more keywords
CCN1 secreted by human adipose‐derived stem cells enhances wound healing and promotes angiogenesis through activating the AKT signalling pathway
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DOI: 10.1111/iwj.14028
Abstract: The study aimed to explore the role of cellular communication network factor 1 (CCN1) an extracellular matrix protein in hADSC‐treated wound healing. Immunofluorescence and enzyme‐linked immunosorbent assays (ELISA) were used to demonstrate the secretion of… read more here.
Keywords: akt signalling; ccn1 secreted; wound healing; hadscs ... See more keywords
LncRNA LINC01305 silencing inhibits cell epithelial‐mesenchymal transition in cervical cancer by inhibiting TNXB‐mediated PI3K/Akt signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14161
Abstract: Cervical cancer (CC) remains one of the leading malignancies afflicting females worldwide, with its aetiology associated with long‐term papillomavirus infection. Recent studies have shifted their focus and research attention to the relationship between long non‐coding… read more here.
Keywords: lncrna linc01305; signalling pathway; akt signalling; pi3k akt ... See more keywords
LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16199
Abstract: Pathological cardiac hypertrophy represents a leading cause of morbidity and mortality worldwide. Liver kinase B1 interacting protein 1 (LKB1IP) was identified as the binding protein of tumour suppressor LKB1. However, the role of LKB1IP in… read more here.
Keywords: cardiac hypertrophy; lkb1ip; hypertrophy; pathological cardiac ... See more keywords