Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12621
Abstract: Angiogenesis plays a critical role in embryo development, tissue repair, tumor growth and wound healing. In the present study, we investigated the role of the serine/threonine kinase Akt in angiogenesis. Silencing of Akt1 in human… read more here.
Keywords: angiogenesis; mural cell; akt1; cell coverage ... See more keywords
Targeting FDFT1 Reduces Cholesterol and Bile Acid Production and Delays Hepatocellular Carcinoma Progression Through the HNF4A/ALDOB/AKT1 Axis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202411719
Abstract: Targeting cholesterol metabolism is a novel direction for tumor therapy. Unfortunately, the current use of statins for hepatocellular carcinoma (HCC) is controversial. Herein, farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) is identified as a novel target for treating… read more here.
Keywords: reduces cholesterol; aldob; bile acid; hepatocellular carcinoma ... See more keywords
Theoretical Investigation of the Structural Characteristics in the Active State of Akt1 Kinase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00506
Abstract: Akt (known as protein kinase B or PKB) is a serine/threonine kinase that regulates multiple biological processes, including cell growth, survival, and differentiation. Akt plays a critical role in the intracellular signaling network through conformational… read more here.
Keywords: state; structural characteristics; kinase; water ... See more keywords
Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells
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DOI: 10.1038/s41598-019-46359-6
Abstract: The signaling mechanisms controlling somatic cell reprogramming are not fully understood. In this study, we report a novel role for mitochondrial Akt1 signaling that enhanced somatic cell reprogramming efficiency. The role of mitochondrial Akt1 in… read more here.
Keywords: somatic cell; cell reprogramming; mito akt1; akt1 ... See more keywords
Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac041
Abstract: Abstract Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whether CAPN7 affects the… read more here.
Keywords: capn7; endometrial stromal; exclusion; akt1 ... See more keywords
P0734THE DELETION OF AKT1 PROMOTES THE RENAL FIBROSIS IN THE MURINE MODEL OF UNILATERAL URETERAL OBSTRUCTION
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0734
Abstract: Previous studies have found the increased Akt activity in experimental renal fibrosis. We investigated the role of Akt1, one of the three Akt isoforms, in renal fibrosis using the murine model of unilateral ureteral obstruction… read more here.
Keywords: akt1 mice; akt1; renal fibrosis; mice ... See more keywords
Progressive frontal intraosseous lipoma: Detection of the mosaic AKT1 variant discloses Proteus syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Genetics"
DOI: 10.1111/cge.14174
Abstract: Proteus syndrome is a very rare disorder with progressive, asymmetrical, and disproportionate overgrowth of body parts with a highly variable phenotype. It is associated with mosaicism for the recurrent heterozygous somatic gain‐of‐function variant c.49G>A (p.Glu17Lys)… read more here.
Keywords: akt1; intraosseous lipoma; proteus syndrome; variant ... See more keywords
Abstract P1-01-19: Predicting response to capivasertib in AKT1 mutant advanced breast cancer
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DOI: 10.1158/1557-3265.sabcs24-p1-01-19
Abstract: Introduction: Activation of the PI3K-AKT and mTOR pathways is a major feature of the biology of breast cancer (BC), with these pathways altered or dysregulated in most BC. Oncogenic mutations in AKT1, most frequently E17K,… read more here.
Keywords: cancer; breast cancer; akt1 mutant; akt1 ... See more keywords
Abstract P5-01-08: Perceptions and behaviors of US oncologists treating HR-positive HER2-negative metastatic breast cancer in second-line
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p5-01-08
Abstract: Background: The emergence of novel targeted therapies for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC) offers more treatment options in second line (2L). While biomarkers can influence 2L treatment… read more here.
Keywords: cancer; treatment; breast cancer; akt1 ... See more keywords
Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis
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DOI: 10.1161/atvbaha.118.310748
Abstract: Objective— The importance of PI3K/Akt signaling in the vasculature has been demonstrated in several models, as global loss of Akt1 results in impaired postnatal ischemia- and VEGF-induced angiogenesis. The ubiquitous expression of Akt1, however, raises… read more here.
Keywords: endothelial cell; autonomous role; akt1; ischemia ... See more keywords
Kaempferol Protects Against Apoptosis in PC12 Cells Exposed to Hydrogen Peroxide by Activating Akt1
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231170448
Abstract: Objective Spinal cord injury (SCI) is a debilitating disease that cannot be cured at present. Kaempferol (KPL) has proven neuroprotective, antioxidant, and antibacterial properties. However, the neuroprotective effect of KPL on SCI and its potential… read more here.
Keywords: apoptosis; pharmacology; akt1; kpl ... See more keywords