Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.
Sign Up to like & getrecommendations! Published in 2023 at "Reproduction"
DOI: 10.1530/rep-22-0353
Abstract: Apoptosis and cell survival regulation are crucial processes during the estrous cycle to prepare a receptive uterus during implantation for successful recognition of pregnancy. PI3K/AKT signaling has a crucial role during gestation and AKT isoforms… read more here.
Keywords: fertility; gland development; estrous cyclicity; akt isoforms ... See more keywords
Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13040493
Abstract: The fusion of 1,2,4-triazole and 1,3,4-thiadiazole rings results in a class of heterocycles compounds with an extensive range of pharmacological properties. A series of 1,2,4-triazolo[3,4-b]-1,2,4-thiadiazoles was synthesized and tested for its enzyme inhibition potential and… read more here.
Keywords: anticancer; akt1 akt2; anticancer activity; triazolo thiadiazoles ... See more keywords