Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death.
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DOI: 10.1126/scisignal.aax7119
Abstract: Progressive degeneration of dopaminergic neurons characterizes Parkinson's disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on poly(ADP-ribose) polymerase-1 (PARP1) called parthanatos. Deficient activity of the kinase… read more here.
Keywords: rnf146 expression; death; akt1 creb; creb pathway ... See more keywords