Articles with "akt1 mutant" as a keyword



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Abstract CT035: A phase Ib study of miransertib (ARQ 092) in combination with anastrozole in patients with PIK3CA or AKT1-mutant ER+ endometrial or ovarian cancer

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Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-ct035

Abstract: Background: Activating PI3K pathway mutations are common in endometrial and a subset of non-serous ovarian cancers and are frequently found in tumors that co-express the estrogen receptor (ER). We evaluated the safety and preliminary efficacy… read more here.

Keywords: combination; endometrial ovarian; pik3ca akt1; ovarian cancer ... See more keywords