AKT2 regulates endothelial-mediated coagulation homeostasis and promotes intrathrombotic recanalization and thrombus resolution in a mouse model of venous thrombosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02112-9
Abstract: Venous thromboembolism (VTE) carries a high risk of morbidity and mortality. Understanding the mechanisms of venous thrombus formation and resolution is critical for improving VTE management. AKT2 kinase is essential for platelet activation and arterial… read more here.
Keywords: resolution; ligated ivc; mice; akt2 ... See more keywords
Anti-inflammatory functions of the CDC25 phosphatase inhibitor BN82002 via targeting AKT2.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.04.007
Abstract: This study presents BN82002 as an anti-inflammatory drug candidate. It was found that BN82002 inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 cells and peritoneal macrophages that were activated… read more here.
Keywords: anti inflammatory; inflammatory functions; bn82002; akt2 ... See more keywords
Abstract 2559: Loss of AKT2 correlates with activation of β-catenin signaling in immortalized mouse hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2559
Abstract: Background: Primary liver cancer is the second most common cause of cancer-related mortality. Abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/AKT and Wnt/β-catenin signaling pathways, which act as key regulators in cell proliferation and growth, is… read more here.
Keywords: activation catenin; akt2; catenin signaling; catenin ... See more keywords
AKT2 drives cancer progression and is negatively modulated by miR-124 in human lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Respiratory Research"
DOI: 10.1186/s12931-020-01491-0
Abstract: Background AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). Accumulating evidence has also revealed that AKT2 can promote NSCLC cell proliferation and metastasis. However, the involved mechanism remains unclear.… read more here.
Keywords: akt2; luad; cancer; mir 124 ... See more keywords
Akt2 causes TGFβ-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression
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DOI: 10.1371/journal.pone.0207285
Abstract: TGFβ promotes podocyte hypertrophy and expression of matrix proteins in fibrotic kidney diseases such as diabetic nephropathy. Both mTORC1 and mTORC2 are hyperactive in response to TGFβ in various renal diseases. Deptor is a component… read more here.
Keywords: podocyte hypertrophy; tgf; expression; downregulation ... See more keywords
Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Endocrinology"
DOI: 10.1530/jme-21-0285
Abstract: Finnish-specific gene variant p.P50T/AKT2 (minor allele frequency (MAF) = 1.1%) is associated with insulin resistance and increased predisposition to type 2 diabetes. Here, we have investigated in vitro the impact of the gene variant on glucose metabolism… read more here.
Keywords: finnish specific; insulin stimulated; akt2; gene variant ... See more keywords