Alanyl-glutamine but not glycyl-glutamine improved the proliferation of enterocytes as glutamine substitution in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2460-z
Abstract: The synthetic dipeptides alanyl-glutamine (Ala-Gln) and glycyl-glutamine (Gly-Gln) are used as Gln substitution to provide energy source in the gastrointestinal tract due to their high solubility and stability. This study aimed to investigate the effects… read more here.
Keywords: gln treatment; gly gln; ala gln; gln ... See more keywords
Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1097/mpg.0000000000002834
Abstract: Objective: Determine the minimum dosage of alanyl-glutamine (Ala-Gln) required to improve gut integrity and growth in children at risk of environmental enteropathy (EE). Methods: This was a double-blinded randomized placebo-controlled dose-response trial. We enrolled 140… read more here.
Keywords: ala gln; alanyl glutamine; day; trial ... See more keywords
Dietary Bioactive Peptide Alanyl-Glutamine Attenuates Dextran Sodium Sulfate-Induced Colitis by Modulating Gut Microbiota
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/5543003
Abstract: Inflammatory bowel disease (IBD) is a chronic intestinal disorder threatening human health. Di-peptide alanyl-glutamine (Ala-Gln) has various beneficial effects on gut health. However, its role and functional mechanism in treating IBD are still not clear.… read more here.
Keywords: peptide alanyl; colitis; ala gln; gln ... See more keywords
Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11061070
Abstract: Acute liver injury is a worldwide problem with a high rate of morbidity and mortality, and effective pharmacological therapies are still urgently needed. Alanyl-glutamine (Ala-Gln), a dipeptide formed from L-alanine and L-glutamine, is known as… read more here.
Keywords: liver injury; ala gln; oxidative stress; mice ... See more keywords
Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14183796
Abstract: Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease with increasing prevalence rates over years and is associated with hepatic lipid accumulation, liver injury, oxidative stress, hepatic inflammation, and liver fibrosis and lack of approved… read more here.
Keywords: inflammation; gln; oxidative stress; ala gln ... See more keywords
Effects of alanyl-glutamine supplementation on the small intestinal mucosa barrier in weaned piglets
Sign Up to like & getrecommendations! Published in 2017 at "Asian-Australasian Journal of Animal Sciences"
DOI: 10.5713/ajas.16.0077
Abstract: Objective The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets. Methods A total of 180 barrows with initial weight 10.01±0.03 kg were randomly… read more here.
Keywords: supplementation; mucosa; gln supplementation; ala gln ... See more keywords