Hypotensive effect induced by microinjection of Alamandine, a derivative of angiotensin-(1–7), into caudal ventrolateral medulla of 2K1C hypertensive rats
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DOI: 10.1016/j.peptides.2017.09.005
Abstract: In the present study we evaluated the cardiovascular effects produced by microinjection of the new component of the renin-angiotensin system, alamandine, into caudal ventrolateral medulla of urethane-anesthetized normotensive and hypertensive 2K1C rats. The participation of… read more here.
Keywords: caudal ventrolateral; alamandine; angiotensin; microinjection ... See more keywords
Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus
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DOI: 10.1016/j.peptides.2019.170101
Abstract: Microinjection of alamandine into the hypothalamic paraventricular nucleus (PVN) increased blood pressure and enhanced sympathetic activity. The aim of this study was to determine if superoxide anions modulate alamandine's effects in the PVN. Mean arterial… read more here.
Keywords: superoxide anions; alamandine; blood pressure; sympathetic activity ... See more keywords
Alamandine protects rat from myocardial ischemia-reperfusion injury by activating JNK and inhibiting NF-κB.
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DOI: 10.26355/eurrev_201908_18563
Abstract: OBJECTIVE: The aim of this study was to investigate whether alamandine plays a protective role in myocardial ischemia-reperfusion injury (IRI) by activating C-Jun N-terminal kinase (JNK) and inhibiting the expression of key proteins in nuclear… read more here.
Keywords: alamandine; myocardial ischemia; reperfusion injury; ischemia reperfusion ... See more keywords
An ACE2-Alamandine Axis Modulates the Cardiac Performance of the Goldfish Carassius auratus via the NOS/NO System
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DOI: 10.3390/antiox11040764
Abstract: Alamandine is a peptide of the Renin Angiotensin System (RAS), either generated from Angiotensin A via the Angiotensin Converting Enzyme 2 (ACE2), or directly from Ang-(1–7). In mammals, it elicits cardioprotection via Mas-related G-protein-coupled receptor… read more here.
Keywords: system; alamandine axis; alamandine; heart ... See more keywords