A tRNA t6A modification system contributes to the sensitivity towards the toxin β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Anabaena sp. PCC 7120.
Sign Up to like & getrecommendations! Published in 2022 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2022.106121
Abstract: Cyanobacteria are oxygen-evolving photosynthetic autotrophs essential for nutrient cycling in the environment. They possess multiple control mechanisms for their cellular activities in order to adapt to the environment. While protein translation is essential for cell… read more here.
Keywords: alanine bmaa; cyanobacterium anabaena; bmaa; t6a ... See more keywords
L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.01.007
Abstract: Background: L‐&bgr;‐N‐methylamino‐L‐alanine (BMAA) is a non‐proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism‐dementia complex (ALS‐PDC) on Guam. Given that natural… read more here.
Keywords: alanine bmaa; alkylating agent; bgr methylamino; bmaa ... See more keywords
Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-L-alanine (BMAA).
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.04.007
Abstract: β-N-methylamino-L-alanine (BMAA), a neurotoxin naturally produced by cyanobacteria, diatoms and dinoflagellates, constitutes a serious environmental and health threat especially during acute blooms, which are becoming more frequent. This neurotoxin is implicated in several neurodegenerative diseases… read more here.
Keywords: alanine bmaa; expression; neurotoxin; bmaa ... See more keywords
Chiral analysis of β-methylamino alanine (BMAA) enantiomers after (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) derivatization and LC-MS/MS
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DOI: 10.1039/c8ay02287a
Abstract: A developed method for chiral analysis of neurotoxin β-methylamino alanine (BMAA) allowed detection of d-BMAA in cycad seed samples. read more here.
Keywords: methylamino alanine; alanine bmaa; chiral analysis; bmaa ... See more keywords
Transfer of the Neurotoxin β-N-methylamino-l-alanine (BMAA) in the Agro–Aqua Cycle
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DOI: 10.3390/md18050244
Abstract: The neurotoxic non-protein amino acid β-N-methylamino-l-alanine (BMAA) is connected to the development of neurodegenerative diseases. BMAA has been shown to accumulate in aquatic ecosystems, and filter-feeding molluscs seem particularly susceptible to BMAA accumulation. The blue… read more here.
Keywords: aqua cycle; agro aqua; alanine bmaa; bmaa ... See more keywords
Occurrence of β-N-methylamino-l-alanine (BMAA) and Isomers in Aquatic Environments and Aquatic Food Sources for Humans
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DOI: 10.3390/toxins10020083
Abstract: The neurotoxin β-N-methylamino-l-alanine (BMAA), a non-protein amino acid produced by terrestrial and aquatic cyanobacteria and by micro-algae, has been suggested to play a role as an environmental factor in the neurodegenerative disease Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia… read more here.
Keywords: bmaa isomers; bmaa; alanine bmaa; aquatic environments ... See more keywords
β-N-Methylamino-L-Alanine (BMAA) Modulates the Sympathetic Regulation and Homeostasis of Polyamines
Sign Up to like & getrecommendations! Published in 2023 at "Toxins"
DOI: 10.3390/toxins15020141
Abstract: The neurotoxin β-N-methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid produced by cyanobacteria. Non-neuronal toxicity of BMAA is poorly studied with a reported increase in reactive oxygen species and a decrease in the antioxidant capacity of… read more here.
Keywords: modulates sympathetic; sympathetic regulation; bmaa; bmaa modulates ... See more keywords