Genetic variations in the alanine–glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis
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DOI: 10.1007/s00726-017-2413-6
Abstract: Rheumatoid arthritis (RA) is associated with high rates of cardiovascular events mainly due to coronary and cerebrovascular atherosclerotic disease. Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines are endogenous inhibitors of nitric oxide synthase and have been… read more here.
Keywords: agxt2 gene; sdma; glyoxylate aminotransferase; alanine glyoxylate ... See more keywords
Crystal Structure Of Photorespiratory Alanine:Glyoxylate Aminotransferase 1 (AGT1) From Arabidopsis thaliana
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DOI: 10.3389/fpls.2019.01229
Abstract: Photorespiration is an energetically costly metabolic pathway for the recycling of phosphoglycolate produced by the oxygenase activity of ribulose-1,5-bisphosphate carboxylase/oxygenase (RUBISCO) to phosphoglycerate. Arabidopsis alanine:glyoxylate aminotransferase 1 (AGT1) is a peroxisomal aminotransferase with a central… read more here.
Keywords: glyoxylate aminotransferase; aminotransferase agt1; glyoxylate; alanine glyoxylate ... See more keywords
Alanine–Glyoxylate Aminotransferase Sustains Cancer Stemness Properties through the Upregulation of SOX2 and OCT4 in Hepatocellular Carcinoma Cells
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DOI: 10.3390/biom12050668
Abstract: Liver cancer stem cells (LCSCs) are a small subset of oncogenic cells with a self-renewal ability and drug resistance, and they promote the recurrence and metastasis of hepatocellular carcinoma (HCC). However, the mechanisms regulating LCSCs… read more here.
Keywords: hepatocellular carcinoma; lcscs; alanine glyoxylate; cancer stemness ... See more keywords
Dimerization Drives Proper Folding of Human Alanine:Glyoxylate Aminotransferase But Is Dispensable for Peroxisomal Targeting
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DOI: 10.3390/jpm11040273
Abstract: Peroxisomal matrix proteins are transported into peroxisomes in a fully-folded state, but whether multimeric proteins are imported as monomers or oligomers is still disputed. Here, we used alanine:glyoxylate aminotransferase (AGT), a homodimeric pyridoxal 5′-phosphate (PLP)-dependent… read more here.
Keywords: dimerization; import; alanine glyoxylate; glyoxylate aminotransferase ... See more keywords