Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9709-6
Abstract: Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; substrate marcks ... See more keywords
A Model for Hysteresis Observed in Phase Transitions of Thermally Responsive Intrinsically Disordered Protein Polymers
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1143
Abstract: A new class of thermally responsive protein based block co-polymers shows tunable hysteresis in their thermal transitions. The sequences encompass intrinsically disordered regions comprising of repeats of Elastin-Like Polypeptides (ELPs). These are interspersed with alpha-helical… read more here.
Keywords: alanine rich; thermally responsive; hysteresis; rich regions ... See more keywords
GARP: A family of glycine and alanine-rich proteins that helps spider mites feed on plants.
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13159
Abstract: Spider mites (Tetranychidae) are destructive agricultural pests which have evolved strategies to overcome plant defenses, such as the ability to puncture the leaves of their hosts to feed. The expression of many genes with unknown… read more here.
Keywords: alanine rich; glycine alanine; rich proteins; spider mites ... See more keywords
A glycine-serine-alanine-rich peptide ameliorates Alzheimer-type neurodegeneration.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16048
Abstract: Repeated amino acid sequences in proteins are widely found, and the glycine–serine–alanine repeat is an element with a general propensity to form β‐sheet aggregates as found in key pathological factors, in several neurodegenerative diseases. Such… read more here.
Keywords: rich peptide; glycine serine; serine alanine; alanine rich ... See more keywords
Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Biomarker Research"
DOI: 10.1186/s40364-021-00286-9
Abstract: The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology. Functioning as a target of protein kinase C,… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; kinase ... See more keywords