The dipeptidyl peptidase IV inhibitory activity and multifunctional antidiabetic properties of SQSPA: Structure - Activity analysis evaluated with alanine scanning.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.05.250
Abstract: Type 2 diabetes is a multifactorial disease and drugs with multifunctional properties are required. The peptide, SQSPA, was reported to be a potent and gastrointestinally stable α-glucosidase inhibitory peptide. In this study, the structure-activity relationship… read more here.
Keywords: inhibitory; alanine scanning; structure activity; dipeptidyl peptidase ... See more keywords
Prediction of Hot Spots at Myeloid Cell Leukemia-1–Inhibitor Interface Using Energy Estimation and Alanine Scanning Mutagenesis
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b01048
Abstract: Myeloid cell leukemia 1 (Mcl1) is an antiapoptotic protein that plays central role in apoptosis regulation. Also, Mcl1 has the potency to resist apoptotic cues resulting in up-regulation and cancer cell protection. A molecular probe… read more here.
Keywords: energy; cell leukemia; myeloid cell; alanine scanning ... See more keywords
Alanine Scanning Effects on the Biochemical and Biophysical Properties of Intrinsically Disordered Proteins: A Case Study of the Histidine to Alanine Mutations in Amyloid-β42
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00926
Abstract: Alanine scanning is a tool in molecular biology that is commonly used to evaluate the contribution of a specific amino acid residue to the stability and function of a protein. Additionally, this tool is also… read more here.
Keywords: alanine; histidine alanine; biochemical biophysical; biophysical properties ... See more keywords
Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00370
Abstract: Mitochondrial serine hydroxymethyl transferase isoform 2 (SHMT2) has attracted increasing attention as a pivotal catalyzing regulator of the serine/glycine pathway in the one-carbon metabolism of cancer cells. However, few inhibitors that target this potential anticancer… read more here.
Keywords: binding mechanism; study shmt2; alanine scanning; shmt2 inhibitors ... See more keywords
Computational alanine scanning interface analysis of T = 3 capsids1.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1007782.s010
Abstract: 1 Results from a KFC2 computational alanine scanning interface analysis of the three quasi-equivalent sites (AA, BC, and CB) in the T = 3 capsids described in this study. Residues identified as hot spots by… read more here.
Keywords: interface analysis; computational alanine; scanning interface; alanine scanning ... See more keywords