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Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01481
Abstract: Postassembly modification of peptides via C(sp3)-H functionalization on aliphatic side chains provides a straightforward approach to access functionalized peptides as therapeutics. However, C(sp3)-H functionalization of C-terminal residues remains underdeveloped due to the inhibition effect of…
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Keywords:
inhibition effect;
ligand enabled;
modification peptides;
alanine terminus ... See more keywords