Principles of tRNAAla Selection by Alanyl–tRNA Synthetase Based on the Critical G3·U70 Base Pair
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DOI: 10.1021/acsomega.9b01827
Abstract: Throughout evolution, the presence of a single G3·U70 mismatch in the acceptor stem of tRNAAla is the major determinant for aminoacylation with alanine by alanyl–tRNA synthetase (AlaRS). Recently reported crystal structures of the complexes AlaRS–tRNAAla/G3·U70… read more here.
Keywords: trna synthetase; alanyl trna; trnaala u70; base pair ... See more keywords
Impact of alanyl-tRNA synthetase editing deficiency in yeast
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DOI: 10.1093/nar/gkab766
Abstract: Abstract Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that provide the ribosome with aminoacyl-tRNA substrates for protein synthesis. Mutations in aaRSs lead to various neurological disorders in humans. Many aaRSs utilize editing to prevent error propagation… read more here.
Keywords: editing deficiency; trna synthetase; alanyl trna; alars editing ... See more keywords
Anti‐alanyl tRNA positive antisynthase syndrome with Kaposi sarcoma
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DOI: 10.1111/1756-185x.13861
Abstract: We report a rare case of antisynthase syndrome (ASS) complicated with Kaposi sarcoma, analyze its clinical characteristics, and review the literature on the topic. An 80‐year‐old male patient developed fever, cough, and shortness of breath.… read more here.
Keywords: sarcoma; antisynthase syndrome; kaposi sarcoma; anti alanyl ... See more keywords
Novel Alanyl-tRNA Synthetase 2 Pathogenic Variants in Leukodystrophies
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DOI: 10.3389/fneur.2019.01321
Abstract: The white matter disease spectrum is associated with many genetic diseases, including AARS2, CADASIL, ALD, and others. In this study, to determine the novel alanyl-tRNA synthetase 2 mutation implicated in white matter disease, several families… read more here.
Keywords: pathogenic variants; chr6; trna synthetase; novel alanyl ... See more keywords