Zinc Oxide Nanoparticles Inhibition of Initial Adhesion and ALS1 and ALS3 Gene Expression in Candida albicans Strains from Urinary Tract Infections
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DOI: 10.1007/s11046-019-00327-w
Abstract: ObjectiveThe aim of this study was to evaluate effects of zinc oxide nanoparticles (ZnO-np) on initiation adhesion and agglutinin-like sequence (ALS) 1 and ALS3 gene expression, which is the first cell surface protein known to… read more here.
Keywords: albicans strains; zno; adhesion; als1 als3 ... See more keywords
Glabridin induces overexpression of two major apoptotic genes, MCA1 and NUC1, in Candida albicans.
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DOI: 10.1016/j.jgar.2017.08.006
Abstract: OBJECTIVES The growing trend in emergence of antifungal-resistant Candida strains has recently inspired researchers to design new antifungal agents with novel mechanisms of action. Glabridin is a natural substrate with multiple biological activities. In this… read more here.
Keywords: glabridin induces; induces overexpression; albicans strains; candida albicans ... See more keywords
Anti‐virulence activity of novel (1‐heteroaryloxy‐2‐hydroxypropyl)‐ phenylpiperazine derivatives against both wild‐type and clinical drug‐resistant Candida albicans strains
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DOI: 10.1111/1751-7915.14169
Abstract: Candida albicans is an important human fungal pathogen. Our previous study disclosed that aryloxy‐phenylpiperazine skeleton was a promising molecule to suppress C. albicans virulence by inhibiting hypha formation and biofilm formation. In order to deeply… read more here.
Keywords: virulence; activity; drug resistant; albicans strains ... See more keywords
Palmarumycin P3 Reverses Mrr1-Mediated Azole Resistance by Blocking the Efflux Pump Mdr1
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DOI: 10.1128/aac.02126-21
Abstract: Palmarumycin P3 (PP3) reduces fluconazole-induced MDR1 transcription to reverse azole resistance in clinical Candida strains. Here, we demonstrated that PP3 restores the susceptibility to several antifungal drugs for Candida albicans strains with gain-of-function mutations in… read more here.
Keywords: albicans strains; palmarumycin; mdr1; azole resistance ... See more keywords
Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1
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DOI: 10.1128/msphere.00095-23
Abstract: As an opportunistic pathogen in humans, the fungus Candida albicans relies on virulence traits to cause disease. They include the ability to transition from yeast to filamentous morphologies and the ability to grow in diverse… read more here.
Keywords: atp analog; protein kinase; ability; kinase ... See more keywords