Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis
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DOI: 10.1038/s41598-018-36933-9
Abstract: Podocyte injury is closely related to proteinuria and the progression of chronic kidney disease (CKD). Currently, there is no conclusive understanding about the mechanisms involved in albumin overload and podocyte apoptosis response. In this study,… read more here.
Keywords: podocyte apoptosis; intracellular albumin; albumin; albumin overload ... See more keywords
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells
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DOI: 10.3390/ijms24119640
Abstract: Besides being a marker of kidney disease severity, albuminuria exerts a toxic effect on renal proximal tubular epithelial cells (RPTECs). We evaluated whether an unfolded protein response (UPR) or DNA damage response (DDR) is elicited… read more here.
Keywords: albumin overload; upr ddr; senescence; epithelial cells ... See more keywords