Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.10.017
Abstract: Summary Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism… read more here.
Keywords: dna damage; alc1; macro domain;
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.71420
Abstract: The chromatin remodeler ALC1 is recruited to and activated by DNA damage-induced poly(ADP-ribose) (PAR) chains deposited by PARP1/PARP2/HPF1 upon detection of DNA lesions. ALC1 has emerged as a candidate drug target for cancer therapy as… read more here.
Keywords: parylated nucleosome; structure; remodeler alc1; alc1 ... See more keywords